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ChemicalBook >> CAS DataBase List >> Nintedanib

Nintedanib

Nintedanib price.
  • $5 - $1490
  • Product name: Nintedanib
  • CAS: 656247-17-5
  • MF: C31H33N5O4
  • MW: 539.64
  • EINECS:1592732-453-0
  • MDL Number:MFCD11974012
  • Synonyms:Nintedanib/Intedanib/Vargatef;BIBF 1120; VARGATEF; INTEDANIB;INTEDANIB BASE;Intedanib Vargatef;Nintedanib, Free Base, >99%;methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate;NTEDANIB;(3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic acid methyl ester;methyl (Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
44 prices
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  • AccelPharmtech
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
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  • Matrix Scientific
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  • 10mM(in 1mL DMSO)
  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging10G
  • Price$430
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging25G
  • Price$780
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberYL1327
  • Product descriptionNintedanib 98%+
  • Packaging50G
  • Price$1490
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-N0321-M025
  • Product descriptionNintedanib(freebase) ≥99%(HPLC)
  • Packaging25mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1091-M050
  • Product descriptionIntedanib ≥95%
  • Packaging50mg
  • Price$702
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ96220
  • Product descriptionVargatef
  • Packaging100mg
  • Price$150
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging100g
  • Price$1105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging25g
  • Price$442
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging5g
  • Price$125
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging1g
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging250mg
  • Price$14
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging100mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging50mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA181556
  • Product descriptionMethyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+%
  • Packaging10mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8252
  • Product descriptionNintedanib(BIBF1120)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8252
  • Product descriptionNintedanib(BIBF1120)
  • Packaging5mg
  • Price$63
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech YL1327 Nintedanib 98%+ 10G $430 2021-12-16 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 25G $780 2021-12-16 Buy
AccelPharmtech YL1327 Nintedanib 98%+ 50G $1490 2021-12-16 Buy
Adipogen Life Sciences CDX-N0321-M025 Nintedanib(freebase) ≥99%(HPLC) 25mg $53 2021-12-16 Buy
Adipogen Life Sciences SYN-1091-M050 Intedanib ≥95% 50mg $702 2021-12-16 Buy
AK Scientific J96220 Vargatef 100mg $150 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 100g $1105 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 25g $442 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 5g $125 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 1g $36 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 250mg $14 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 100mg $9 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 50mg $7 2021-12-16 Buy
Ambeed A181556 Methyl(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 99+% 10mg $5 2021-12-16 Buy
ApexBio Technology A8252 Nintedanib(BIBF1120) 1unit $28 2021-12-16 Buy
ApexBio Technology A8252 Nintedanib(BIBF1120) 5mg $63 2021-12-16 Buy

Properties

Melting point :>237oC (dec.)
Boiling point :742.2±60.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Yellow solid.
pka :11.06±0.20(Predicted)
color :Light Yellow to Light Green
InChIKey :XZXHXSATPCNXJR-ZIADKAODSA-N
SMILES :C(/C1C=CC=CC=1)(=C1\C(NC2=CC(C(=O)OC)=CC=C\12)=O)\NC1C=CC(N(C)C(=O)CN2CCN(C)CC2)=CC=1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Nintedanib is an oral administrated triple tyrosine kinase inhibitors developed by Boehringer Ingelheim, Germany. Its targets include platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and basic fiber (BFGF), being able to also inhibit the activation of MAPK and Akt. At present, it is mainly used for cancer treatment, such as colorectal cancer, ovarian cancer and multiple myeloma. The study regarding to the respiratory diseases mainly focuses on the clinical treatment of advanced non-small cell lung cancer (NSCLC) and idiopathic pulmonary fibrosis (IPF). In June 2014, Boehringer Ingelheim has announced that the marketing authorization application of Nintedanib for the treatment of Idiopathic Pulmonary Fibrosis (IPF) had been confirmed by the European Medicines Agency (EMA) and been included in the accelerated approval list by the EMA.

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