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ChemicalBook >> CAS DataBase List >> PLX-4720

PLX-4720

PLX-4720 price.
  • $44 - $1133.9
  • Product name: PLX-4720
  • CAS: 918505-84-7
  • MF: C17H14ClF2N3O3S
  • MW: 413.83
  • EINECS:
  • MDL Number:MFCD14635203
  • Synonyms:1-PropanesulfonaMide, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-;N-[3-[(5-Chloro-1H-pyrrol...;N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide PLX 4720;PLX 4720 N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide;PLX4720, >=98%;Raf Kinase Inhibitor V;PLX-4720, N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide;N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
22 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Usbiological
Package
  • 1mg
  • 2mg
  • 10mM(in 1mL DMSO)
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3577-M025
  • Product descriptionPLX4720 ≥99%(HPLC)
  • Packaging25mg
  • Price$255
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7406
  • Product descriptionPLX-4720
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3016
  • Product descriptionPLX-4720
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60059
  • Product descriptionPLX-4720 ≥98%
  • Packaging10mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1474
  • Product descriptionPLX4720 99%
  • Packaging2mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154747
  • Product descriptionPLX-4720 >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154747
  • Product descriptionPLX-4720 >99%
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154747
  • Product descriptionPLX-4720 >99%
  • Packaging1g
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC34125
  • Product descriptionPLX 4720
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC34125
  • Product descriptionPLX 4720
  • Packaging50mg
  • Price$332.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15142
  • Product descriptionPLX4720 ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15142
  • Product descriptionPLX4720 ≥95%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15142
  • Product descriptionPLX4720 ≥95%
  • Packaging10mg
  • Price$138
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15142
  • Product descriptionPLX4720 ≥95%
  • Packaging25mg
  • Price$299
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0094
  • Product descriptionPLX-4720 99.88%
  • Packaging10mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0094
  • Product descriptionPLX-4720 99.88%
  • Packaging50mg
  • Price$120
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3577-M025 PLX4720 ≥99%(HPLC) 25mg $255 2021-12-16 Buy
AK Scientific X7406 PLX-4720 5mg $60 2021-12-16 Buy
ApexBio Technology A3016 PLX-4720 10mM(in 1mL DMSO) $90 2021-12-16 Buy
Arctom CFN60059 PLX-4720 ≥98% 10mg $168 2021-12-16 Buy
Axon Medchem Axon1474 PLX4720 99% 2mg $55 2021-12-16 Buy
Biorbyt Ltd orb154747 PLX-4720 >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb154747 PLX-4720 >99% 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb154747 PLX-4720 >99% 1g $1133.9 2021-12-16 Buy
Biosynth Carbosynth FC34125 PLX 4720 10mg $95 2021-12-16 Buy
Biosynth Carbosynth FC34125 PLX 4720 50mg $332.5 2021-12-16 Buy
Cayman Chemical 15142 PLX4720 ≥95% 1mg $44 2024-03-01 Buy
Cayman Chemical 15142 PLX4720 ≥95% 5mg $109 2024-03-01 Buy
Cayman Chemical 15142 PLX4720 ≥95% 10mg $138 2024-03-01 Buy
Cayman Chemical 15142 PLX4720 ≥95% 25mg $299 2024-03-01 Buy
ChemScene CS-0094 PLX-4720 99.88% 10mg $56 2021-12-16 Buy
ChemScene CS-0094 PLX-4720 99.88% 50mg $120 2021-12-16 Buy

Properties

Melting point :230-233oC
Density :1.55
storage temp. :+2C to +8C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
form :Orange-yellow solid
pka :6.20±0.10(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of wild type B-Raf. PLX4720 is an orally-available, highly selective inhibitor of B-RafV600E (IC50 = 13 nM). It is less effective against wild type B-Raf (IC50 = 160 nM) as well as several other kinases. PLX4720 induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of B-Raf.

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