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ChemicalBook >> CAS DataBase List >> Ibrutinib

Ibrutinib

Ibrutinib price.
  • $5 - $1208.7
  • Product name: Ibrutinib
  • CAS: 936563-96-1
  • MF: C25H24N6O2
  • MW: 440.5
  • EINECS:805-642-2
  • MDL Number:MFCD20261150
  • Synonyms:According to Lu imatinib;2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-;PCI-32765 (Ibrutinib);IBRUTINIB;1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one;1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib (PCI32765);PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
42 prices
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  • A1 Biochem Labs
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AvaChem
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  • Biorbyt Ltd
  • Biosynth Carbosynth
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  • ManufacturerA1 Biochem Labs
  • Product number6565111
  • Product descriptionPCI-32765 95%
  • Packaging5G
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3620-M025
  • Product descriptionIbrutinib ≥98%(HPLC)
  • Packaging25mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ97283
  • Product descriptionIbrutinib(PCI-32765)
  • Packaging1g
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging10mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging50mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging100mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging250mg
  • Price$21
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging1g
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging5g
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150396
  • Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
  • Packaging10g
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3001
  • Product descriptionPCI-32765(Ibrutinib)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60061
  • Product descriptionIbrutinib(PCI-32765)
  • Packaging20mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3371
  • Product descriptionIbrutinib
  • Packaging10mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3371
  • Product descriptionIbrutinib
  • Packaging25mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3371
  • Product descriptionIbrutinib
  • Packaging100mg
  • Price$55
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A1 Biochem Labs 6565111 PCI-32765 95% 5G $180 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3620-M025 Ibrutinib ≥98%(HPLC) 25mg $320 2021-12-16 Buy
AK Scientific J97283 Ibrutinib(PCI-32765) 1g $90 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 5mg $5 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 10mg $7 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 50mg $9 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 100mg $15 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 250mg $21 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 1g $56 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 5g $254 2021-12-16 Buy
Ambeed A150396 (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% 10g $475 2021-12-16 Buy
ApexBio Technology A3001 PCI-32765(Ibrutinib) 1unit $28 2021-12-16 Buy
Arctom CFN60061 Ibrutinib(PCI-32765) 20mg $70 2021-12-16 Buy
AvaChem 3371 Ibrutinib 10mg $35 2021-12-16 Buy
AvaChem 3371 Ibrutinib 25mg $45 2021-12-16 Buy
AvaChem 3371 Ibrutinib 100mg $55 2021-12-16 Buy

Properties

Melting point :153-158°C
Boiling point :715.0±60.0 °C(Predicted)
Density :1.34
storage temp. :-20°C
solubility :Soluble in DMSO ( up to at least 25 mg/ml)
form :solid
pka :4.09±0.30(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :XYFPWWZEPKGCCK-GOSISDBHSA-N
SMILES :C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C
CAS DataBase Reference :936563-96-1

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P501 Dispose of contents/container to..…

Description

Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation, promoting apoptosis and preventing homing to the protective tumor microenvironment, at concentrations that do not affect T cell receptor signaling (1,000-fold more potent). It has been reported to inhibit autophosphorylation of BTK (IC50 = 11 nM), phosphorylation of PLCγ (IC50 = 29 nM), a substrate of BTK, and phosphorylation of ERK (IC50 = 13 nM), a further downstream kinase. Its use has been examined clinically for the treatment of diseases associated with B cell antigen receptor signaling, including mantle cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkin lymphoma.

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