Trametinib
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- $28 - $4391.1
- Product name: Trametinib
- CAS: 871700-17-3
- MF: C26H23FIN5O4
- MW: 615.39
- EINECS:
- MDL Number:MFCD17215075
- Synonyms:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide GSK-1120212;Trametinib (GSK1120212,JTP 74057);Trametinib, >=98%;Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-;N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-tri;N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide;TraMetinib;GSK-1120212(traMetinib,JTP-74057)
52 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 1unit
- 1mg
- 5mg
- 2x5mg
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 200mg
- 250mg
- 500mg
- 10mM(in 1mL DMSO)
- 1g
- 2g
- 5G
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1170-M001
- Product descriptionGSK1120212 ≥95%
- Packaging1mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1170-M010
- Product descriptionGSK1120212 ≥95%
- Packaging10mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7454
- Product descriptionTrametinib
- Packaging25mg
- Price$81
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53176
- Product descriptionTrametinib
- Packaging1g
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3018
- Product descriptionTrametinib(GSK1120212)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3018
- Product descriptionTrametinib(GSK1120212)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60051
- Product descriptionTrametinib(GSK1120212) ≥98%
- Packaging10mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging5mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging10mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging25mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging100mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3376
- Product descriptionTrametinib
- Packaging1g
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1761
- Product descriptionGSK1120212-Trametinib|JTP74057 99%
- Packaging2x5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1761
- Product descriptionGSK1120212-Trametinib|JTP74057 99%
- Packaging2x25mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546250
- Product descriptionTrametinib >98%
- Packaging10mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb153631
- Product descriptionTrametinib >99% pure
- Packaging10mg
- Price$297.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1170-M001 | GSK1120212 ≥95% | 1mg | $86 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1170-M010 | GSK1120212 ≥95% | 10mg | $221 | 2021-12-16 | Buy |
| AK Scientific | X7454 | Trametinib | 25mg | $81 | 2021-12-16 | Buy |
| AK Scientific | J53176 | Trametinib | 1g | $450 | 2021-12-16 | Buy |
| ApexBio Technology | A3018 | Trametinib(GSK1120212) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A3018 | Trametinib(GSK1120212) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| Arctom | CFN60051 | Trametinib(GSK1120212) ≥98% | 10mg | $118 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 5mg | $29 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 10mg | $39 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 25mg | $49 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 100mg | $95 | 2021-12-16 | Buy |
| AvaChem | 3376 | Trametinib | 1g | $385 | 2021-12-16 | Buy |
| Axon Medchem | Axon1761 | GSK1120212-Trametinib|JTP74057 99% | 2x5mg | $110 | 2021-12-16 | Buy |
| Axon Medchem | Axon1761 | GSK1120212-Trametinib|JTP74057 99% | 2x25mg | $330 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546250 | Trametinib >98% | 10mg | $136 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb153631 | Trametinib >99% pure | 10mg | $297.5 | 2021-12-16 | Buy |
Properties
Melting point :300-301 °C
Density :1.74
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :White solid.
pka :14.76±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :LIRYPHYGHXZJBZ-UHFFFAOYSA-N
SMILES :C(NC1=CC=CC(N2C3=C(C)C(=O)N(C)C(NC4=CC=C(I)C=C4F)=C3C(=O)N(C3CC3)C2=O)=C1)(=O)C
Density :1.74
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :White solid.
pka :14.76±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :LIRYPHYGHXZJBZ-UHFFFAOYSA-N
SMILES :C(NC1=CC=CC(N2C3=C(C)C(=O)N(C)C(NC4=CC=C(I)C=C4F)=C3C(=O)N(C3CC3)C2=O)=C1)(=O)C
Safety Information
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Description
The dual specificity mitogen-activated protein kinase kinases (MEK) isoforms MEK1 and MEK2 function in a RAS/RAF/MEK/ERK signaling pathway to control cell growth, survival, and differentiation. Trametinib is a potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC50s = 0.7 and 0.9 nM, respectively). It shows specificity for MEK1/2 over a panel of more than 180 kinases, including B-Raf, c-Raf, and MEK5. Trametinib blocks dual phosphorylation of ERK1/2 and stops cell cycling in cancer cell lines, both in vitro and in multiple tumor models in mice. Trametinib, alone or in combination with other chemotherapeutic drugs, targets a subset of cancer cells that can be characterized by specific biomarkers, such as B-Raf, RAS, or CTNNB1 mutations.Related product price
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![N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide](https://img.chemicalbook.com/ProductImageEN/2018-12/small/fe498182-1055-4d7c-bbd5-8bbb37f80631.png){kind=small}
