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CAS No. : | 656247-17-5 | MDL No. : | MFCD11974012 |
Formula : | C31H33N5O4 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | CPMDPSXJELVGJG-UHFFFAOYSA-N |
M.W : | 539.62 | Pubchem ID : | 135423438 |
Synonyms : |
Intedanib; Nintedanib
|
Chemical Name : | Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P201-P202-P260-P264-P270-P280-P301+P310+P330-P302+P352-P305+P351+P338+P310-P308+P313-P332+P313-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301-H315-H318-H361-H372 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90.8% | In methanol; for 8.0h;Reflux; | 3-[ 1 -Methoxy- 1 -phenyl-meth-(E)-ylidene]-2-oxo-2,3 -dihydro- 1 H-indole-6-carboxylic acid methyl ester (195.0 g / 0.6304 mol) and N-(4-amino-phenyl)-N-methyl-2-(4-methyl- piperazin-l-yl)-acetamide (169.5 g / 1.025 eq) were stirred in MeOH (1753.95 ml) at reflux until complete conversion (~ 8h). The suspension was cooled to ambient temperature and than stirred at 0C for 2 hours. The precipitated product was filtered off and washed with ice cold MeOH and Et20 and dried in vacuum at 60C to obtain 309.05 g (90.8 %) of Intedanib. |