946518-60-1
中文名稱
IKK2抑制劑（LY2409881）
英文名稱
LY2409881 trihydrochloride
CAS
946518-60-1
分子式
C24H32Cl4N6OS
分子量
521.51
MOL 文件
946518-60-1.mol
更新日期
2024/12/18 10:29:51
946518-60-1 結(jié)構(gòu)式
基本信息
中文別名
LY2409881三鹽酸鹽IKK2抑制劑(LY2409881)
化合物L(fēng)Y2409881 TRIHYDROCHLORIDE
2-(5-氯-2-((3-(4-甲基哌嗪-1-基)丙基)氨基)嘧啶-4-基)-N-環(huán)丙基苯并[B]噻吩-4-羧酰胺 三鹽酸鹽
2-[5-氯-2-[[3-(4-甲基-1-哌嗪基)丙基]氨基]-4-嘧啶基]-N-環(huán)丙基-苯并[B]噻吩-4-甲酰胺三鹽酸鹽
英文別名
LY2409881CS-1620
LY2409881 3HCl
LY-2409881 HC'l
LY2409881 triHCl
LY-2409881
LY 2409881
LY2409881 trihydrochloride
LY2409881 trihydrochloride USP/EP/BP
2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide
2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
所屬類別
生物化工：IκB/IKK 抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度≥59.4 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
形態(tài)固體
顏色Light yellow to yellow
常見問題列表
生物活性
LY2409881 是一種有效的選擇性 IKK2 抑制劑，IC50 為 30 nM，選擇性比IKK1和其他常見激酶高10倍多。體外研究
LY2409881 inhibits constitutively activated NF-?B, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.體內(nèi)研究
In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) signi?cantly inhibits the tumor growth.IKK2抑制劑（LY2409881）價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-B0788A | IKK2抑制劑（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 5mg | 800元 |
| 2024/11/08 | HY-B0788A | IKK2抑制劑（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 10mM * 1mLin DMSO | 1046元 |
| 2024/11/08 | HY-B0788A | IKK2抑制劑（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 10mg | 1280元 |