1346133-11-6
中文名稱
1346133-11-6
英文名稱
(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
CAS
1346133-11-6
分子式
C24H22F2N2O2
分子量
408.44
MOL 文件
1346133-11-6.mol
更新日期
2024/10/28 15:49:03
1346133-11-6 結(jié)構式
基本信息
中文別名
化合物 T11909化合物LY2444296
(S)-3-氟-4-(4-((2-(3-氟苯基)吡咯烷-1-基)甲基)苯氧基)苯甲酰胺
英文別名
FP3FBZLY2444296
(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
物理化學性質(zhì)
沸點491.6±45.0 °C(Predicted)
密度1.276±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度Ethanol: 27.5 mg/mL (67.33 mM); Methanol: 5 mg/mL (12.24 mM)
酸度系數(shù)(pKa)15.61±0.50(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
生物活性
LY2444296 是一種有口服生物活性、高親和力、選擇性的短效的 KOPR 拮抗劑，其 Ki 值為 ~1 nM。LY2444296 具有抗焦慮樣的作用。靶點
Ki: ~1 nM (KOPR)
體內(nèi)研究
LY2444296 displays anti-anxiety like effects in the EPM test.
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-na?ve rats.
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-na?ve rats.
| Animal Model: | Adult male Sprague Dawley rats (240–250 g) |
| Dosage: | 3 mg/kg |
| Administration: | Injected intraperitoneally; 30 min before U69,593 administration |
| Result: | Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-na?ve rats. |