73285-50-4
中文名稱
去氧野艽霉素鹽酸鹽
英文名稱
Deoxynojirimycin hydrochloride
CAS
73285-50-4
分子式
C6H13NO4
分子量
163.17
MOL 文件
73285-50-4.mol
更新日期
2024/12/16 10:53:12
73285-50-4 結(jié)構(gòu)式
基本信息
中文別名
野尻霉素脫氧野尻霉素
鹽酸脫氧野尻霉素
脫氧野尻霉素鹽酸鹽
去氧野艽霉素鹽酸鹽
英文別名
DNJDNM
DNM1
1-DNJ
AT 2220
DNJ, HCL
B-dynamin
DEOXYNOJIRIMYCIN
DEOXYNOJIRIMICIN
Dynamin BREDNM19
所屬類別
生物化工：中草藥成分物理化學(xué)性質(zhì)
熔點(diǎn)195-196°C
儲(chǔ)存條件2-8°C
溶解度可微溶于水
形態(tài)粉末
顏色白色
水溶解性Soluble in water at 20mg/ml
BRN3563225
穩(wěn)定性吸濕性
CAS 數(shù)據(jù)庫(kù)73285-50-4
常見(jiàn)問(wèn)題列表
生物活性
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) 是一種口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制劑。1-Deoxynojirimycin hydrochloride 抑制餐后血糖，預(yù)防糖尿病。1-Deoxynojirimycin hydrochloride 具有降血糖、減肥和抗病毒的作用。體內(nèi)研究
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect .
1-Deoxynojirimycin hydrochloride significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice.
| Animal Model: | db/db mice |
| Dosage: | 20, 40, 80 mg/kg |
| Administration: | Intravenously; daily for four weeks |
| Result: | Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance. |