481-74-3
481-74-3 結(jié)構(gòu)式
基本信息
大黃酚
大黃酚(大黃根酸)
1,8-二羥基-3-甲基-蒽醌
大黃根酚
大黃根酸
驅(qū)蟲(chóng)豆酸
3-甲金黃異茜素
大黃根酚
大黃根酸
1,8-二羥-3-甲蒽醌
顯金黃酸
1,8-DIHYDROXY-3-METHYLANTHRAQUINONE
3-METHYLCHRYSAZIN
3-METHYLCHRYSAZINE
9,10-ANTHRACENEDIONE,1,8-DIHYDROXY-3-METHYL
CHRYSOPHANIC ACID
CHRYSOPHANOL
RHUBARB EXTRACT
1,8-dihydroxy-3-methyl-10-anthracenedione
1,8-Dihydroxy-3-methyl-9,10-anthraquinone
1,8-dihydroxy-3-methyl-anthraquinon
2-Methyl-4,5-dihydroxyanthraquinone
3-Methyl-1,8-dihydroxyanthraquinone
4,5-Dihydroxy-2-methylanthraquinone
Anthraquinone,1,8-dihydroxy-3-methyl-
c.i.75400
c.i.naturalyellow23
Chrysophansαure
turkeyrhubarb
CHRYSOPHANOL:9,10-ANTHRACENEDIONE,1,8-DIHYDROXY-3-METHYL
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
| Target | Value |
| EGFR | |
| mTOR |
Chrysophanic acid (Chrysophanol)是EGFR/mTOR通路抑制劑。Chrysophanic acid (Chrysophanol)是一種天然的蒽醌化合物，在EGFR過(guò)表達(dá)的SNU-C5人類結(jié)腸癌細(xì)胞中具有抗癌活性。Chrysophanic acid (Chrysophanol)優(yōu)先阻斷SNU-C5細(xì)胞的增殖，但不會(huì)阻斷EGFR表達(dá)水平較低的其他細(xì)胞系(HT7，HT29，KM12C，SW480，HCT116和SNU-C4)的增殖。Chrysophanic acid (Chrysophanol)處理SNU-C5細(xì)胞能夠抑制EGFR中EGF誘導(dǎo)的磷酸化，并抑制下游信號(hào)分子，如AKT，細(xì)胞外信號(hào)調(diào)節(jié)激酶(ERK)以及哺乳動(dòng)物類雷帕霉素靶蛋白(mTOR)/核糖體蛋白S6激酶(p70S6K)的活化。 在BGM(Buffalo green monkey)腎臟細(xì)胞中，Chrysophanic acid也能夠抑制Ⅱ和Ⅲ型脊髓灰質(zhì)炎病毒(小RNA病毒科)以及脊髓灰質(zhì)炎病毒誘導(dǎo)的細(xì)胞病理效應(yīng)。
Chrysophanol (CA) improves HFD-induced obesity in C57BL/6 Mice. The in vivo performance of Chrysophanol is performed in male C57BL/6J mice to determine the efficacy of administered Chrysophanol. Mice fed the HFD gained significantly more weight than those fed the standard diet mice. On the other hand, weight gain of Chrysophanol group is significantly less than with the untreated HFD. Mice in the HFD-group gained 23.92 ± 1.74 g of weight, while those in the Chrysophanol group gained 16.72±2 g of weight after 16 weeks.
知名試劑公司產(chǎn)品信息
Chrysophanic acid, 98%(481-74-3)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/11 | XW04817433 | 大黃酚 chrysophanic acid;1,8-dihydroxy-3-methylanthraquinone | 481-74-3 | 250MG | 358元 |
| 2024/11/11 | XW04817432 | 大黃酚 chrysophanic acid;1,8-dihydroxy-3-methylanthraquinone | 481-74-3 | 50MG | 99元 |
| 2024/11/08 | HY-13595 | 大黃酚 Chrysophanol | 481-74-3 | 50mg | 400元 |