3347-22-6
3347-22-6 結(jié)構(gòu)式
基本信息
二氰蒽醌
二噻農(nóng)
2,3-二腈基-1,4-二硫代蒽醌
5,10-二氫-5,10-二氧萘基[2,3-B]-1,4-二硫雜環(huán)-2,3-二腈
75%二氰蒽醌可濕性粉劑
二氰蒽醌懸浮劑
2,3-DICYANO-1,4-DITHIAANTRAQUINONE
5,10-DIHYDRO-5,10-DIOXONAPHTHO-[2,3-B]-1,4-DITHIIN-2,3-DICARBONITRILE
5,10-DIHYDRO-5,10-DIOXONAPHTHO[2,3-B]-P-DITHIIN-2,3-DICARBONITRILE
5,10-DIOXO-5,10-DIHYDRO-NAPHTHO[2,3-B][1,4]DITHIINE-2,3-DICARBONITRILE
AKOS NCG1-0094
AKTUAN
CLUSTER
DELAN
DELAN-COL
DELAN(R)
Dicyano-1,4-dithia-anthraquinone
dithiaanthraquinone-2,3-dinitrile
DITHIANON
1,4-dithiaanthraquinone-2,3-dicarbonitrile
1,4-dithiaanthraquinone-2,3-dinitrile
2,3-dicarbonitrilo-1,4-diathiaanthrachinon
2,3-dinitrilo-1,4-dithia-9,10-anthraquinone
2,3-dinitrilo-1,4-dithiaanthraquinone
2,3-dinitrilo-1,4-dithia-anthraquinone
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
二氰蒽醌(dithianon)，試驗(yàn)代號 BAS216F、CL37114、CME107、IT-931、MV119A SAG107。商品名稱 Agrition、Delan、Ditho、Dock、Fado、Kuki、Minosse、Zot。其他名稱二噻農(nóng)，是由BASF公司開發(fā)的殺菌劑。
二氰蒽醌純品為深棕色結(jié)晶狀固體，具有銅的光澤(工業(yè)品淺棕色)，熔點(diǎn) 215~216℃；蒸氣壓2.7X10mPa。分配系數(shù) KowlgP=3.2，Henry常數(shù)5.71X10Pam/mol(計算值) 相對密度1.576kg/m(20C)。水中溶解度(pH 7,20C):0.14mg/L。有機(jī)溶劑溶解度(g/L. 20C):甲苯8，氯仿12，丙酮 10;微溶于甲醇和二氯甲烷。濃酸、堿性介質(zhì)中及長時間加熱會 分解，DTs,12.2h(pH7,25C)。穩(wěn)定存在至80℃。水溶液(0.1mg/L)暴露于人造光下時 DT50 19h。閃點(diǎn)>300℃。
二氰蒽醌以蔡為原料，經(jīng)如下反應(yīng)即制得目的物。
大鼠急性經(jīng)口LD50>300mg/kg，大鼠急性經(jīng)皮 LD50>2000mg/kg。對皮膚無刺激對眼嚴(yán)重刺激。雄性大鼠吸入LC50(4h)0.28mg/L空氣。NOEL[2y,mg/(kg·d)]:大鼠(2y)1. 狗(ly)1.6，小鼠(1.5y)2.8。ADI0.01mg/kg。無遺傳毒性。制劑毒性:輕度急性經(jīng)口毒性，無 生殖、發(fā)育毒性，無致癌性。
Reactive oxygen species (ROS)
Colletotrichum sp.
;
Elsinoe ampelina
;
Plasmopara viticola
;
Phomopsis viticola
When exponentially aerobic growing cells of
S. cerevisiae
are submitted to acute Dithianon treatment they loss cell wall and membrane integrity, dying by necrosis, and this behavior is associated to a depletion of reduced proteic and non-proteic thiol groups. An important increase of cellular reactive oxygen species (ROS) associated to mitochondrial membrane potential modifications on Dithianon treated cells are also detected.
In filamentous fungus, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells showed that Dithianon inhibits respiration and fermentation affecting several thiol enzymes of the glycolytic pathway as hexokinase, phosphofructokinase, and glyceraldeyde-3-phosphate dehydrogenase.
Dithianon has in vitro cytotoxic effect and affect cell transforming activity of BLAB/c 3 T3 cells.
The activity of testosterone hydroxylase of liver microsomes derived from male mice is increased when they are treated with acute doses of Dithianon, while in females an inactivating effect is observed.