2309-07-1
中文名稱
阿魏酸甲酯
英文名稱
FERULIC ACID METHYL ESTER
CAS
2309-07-1
分子式
C11H12O4
MDL 編號
MFCD00017208
分子量
208.21
MOL 文件
2309-07-1.mol
更新日期
2025/01/24 10:07:42
2309-07-1 結(jié)構(gòu)式
基本信息
中文別名
阿魏酸甲酯4-羥基-3-甲氧基肉桂酸甲酯
英文別名
4-HYDROXY-3-METHOXYCINNAMIC ACID METHYL ESTERFERULIC ACID METHYL ESTER
METHYL 3-(4-HYDROXY-3-METHOXY)CINNAMATE
METHYL 4-HYDROXY-3-METHOXYCINNAMATE
METHYL FERULATE
METHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)-ACRYLATE
3-(4-hydroxy-3-methoxyphenyl)-2-propenoicacimethylester
4-hydroxy-3-methoxy-cinnamicacimethylester
3-(3-Methoxy-4-hydroxyphenyl)acrylic acid methyl ester
3-(4-Hydroxy-3-methoxyphenyl)propenoic acid methyl ester
3-Methoxy-4-hydroxybenzeneacrylic acid methyl ester
Maritin F
Fumalic acid methyl ester
所屬類別
生物化工：提取物物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于番杏科(Aizoaceae) 番杏 Tetragonia tetragonoides (Pall.)O.kuntze 葉。
熔點(diǎn)62-65°C
沸點(diǎn)163 °C(Press: 1 Torr)
密度1.204±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
溶解度Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Sparingly)
酸度系數(shù)(pKa)8.88±0.18(Predicted)
形態(tài)固體
顏色白色至灰白色
水溶解性Slightly soluble in water.
LogP2.209 (est)
CAS 數(shù)據(jù)庫2309-07-1(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester(2309-07-1)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)類別碼R36/37/38
安全說明S26-S36/37/39
RTECS號GD9470000
海關(guān)編碼2918999090
常見問題列表
生物活性
Ferulic acid methyl ester (Methyl ferulate) 是從 Stemona tuberosa 中分到的阿魏酸衍生物，具有抗氧化、抗炎作用。Ferulic acid methyl ester 能夠透過細(xì)胞膜和血腦屏障，清除自由基，可用于神經(jīng)退行性疾病的研究。在原發(fā)性骨髓源性巨噬細(xì)胞中，F(xiàn)erulic acid methyl ester 抑制 COX-2 的表達(dá)，降低 p-p38 和 p-JNK 的水平。靶點(diǎn)
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p38
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體外研究
Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.
Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).
Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.
Cell Viability Assay
| Cell Line: | Primary bone marrow derived-macrophages (BMDMs) |
| Concentration: | 25 μg/mL |
| Incubation Time: | 6 h, 18 h, 48 h |
| Result: | Showed no cytotoxic effects on BMDMs. |
Western Blot Analysis
| Cell Line: | RAW 246.7 cells |
| Concentration: | 10 μg/mL and 25 μg/mL |
| Incubation Time: | For 1 h before stimulation with LPS |
| Result: | Significantly suppressed COX-2 expression at 25 μg/mL. |