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2203-97-6

中文名稱 氫化可的松琥珀酸酯
英文名稱 Hydrocortisone 21-hemisuccinate
CAS 2203-97-6
分子式 C25H34O8
分子量 462.53
MOL 文件 2203-97-6.mol
更新日期 2024/12/25 19:46:27
2203-97-6 結(jié)構(gòu)式 2203-97-6 結(jié)構(gòu)式

基本信息

中文別名
氫可琥珀酸酯
琥珀酸氫化可的松
氫化可的松琥珀酸酯
羥基可的松琥珀酸酯
氫化可的松氫琥珀酸鹽
氫化可的松半琥珀酸酯
氫化可的松半瑚珀酸酯
氫化可的松琥珀酸酯 1G
氫化可的松半琥珀酸酯無(wú)水
氫化可松琥珀氫 EP標(biāo)準(zhǔn)品
英文別名
C12888
saxizon
NSC 7576
-2-oxoethoxy)
cortisolsuccinate
Hydrocortisone 21-he
CORTISOL HEMISUCCINATE
HYDROCORTISONE SUCCINATE
Hydrocortizone Succinate
CORTISOL 21-HEMISUCCINATE
所屬類別
原料藥:腎上腺皮質(zhì)激素類藥

物理化學(xué)性質(zhì)

熔點(diǎn)170~172℃
比旋光度[α]D20 +147~+153° (c=1, C2H5OH) (After Drying)
沸點(diǎn)685.5±55.0 °C(Predicted)
密度1.33±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.
酸度系數(shù)(pKa)pKa 5.10/5.64(20% aq EtOH/50% aq EtOH) (Uncertain)
形態(tài)neat
顏色白色至灰白色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H360D
安全說(shuō)明22-24/25
WGK Germany3
RTECS號(hào)TU5010147

應(yīng)用領(lǐng)域

用途1
用作醫(yī)藥中間體

常見問(wèn)題列表

用途

氫化可的松琥珀酸酯是一種皮質(zhì)類固醇,用作分析和色譜試劑。

生物活性
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate),一種糖皮質(zhì)激素, 是口服活性的甾體抗炎劑 (SAID)。Hydrocortisone hemisuccinate 抑制 IL-6 和 IL-3 的生物活性,IC50 值分別為 6.7 和 21.4 μM。Hydrocortisone hemisuccinate 可用于潰瘍性結(jié)腸炎 (UC) 的研究。
靶點(diǎn)

IL-6

6.7 μM (IC 50 )

IL-3

21.4 μM (IC 50 )

體外研究

Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC 50 s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.
Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.

體內(nèi)研究

Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.

Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis
Dosage: 30 mg/kg
Administration: P.o. twice daily for 5 days
Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
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