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53-06-5

中文名稱 可的松
英文名稱 CORTISONE
CAS 53-06-5
EINECS 編號(hào) 200-162-4
分子式 C21H28O5
MDL 編號(hào) MFCD00003610
分子量 360.44
MOL 文件 53-06-5.mol
更新日期 2024/11/05 14:06:37
53-06-5 結(jié)構(gòu)式 53-06-5 結(jié)構(gòu)式

基本信息

中文別名
17-羥-11脫氫皮質(zhì)(甾)酮
可的松
腎上腺皮質(zhì)激素
11-去氫-17-羥基皮質(zhì)酮
17-羥-11-脫皮質(zhì)(甾)酮
11-去氫-17-羥皮質(zhì)甾酮
可體松
皮質(zhì)酮
17Α,21-二羥-4-孕烯-3,11,20-三酮
11-去氫-17-羥基皮質(zhì)酮,11-DEHYDRO-17-HYDROXYCORTICOSTERONE
17Α,21-二羥基-4-孕甾烯-2,11,20-三酮,17Α,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
英文別名
11-DEHYDRO-17-HYDROXYCORTICOSTERONE
17A 21-DIHYDROXY-4-PREGNEN-3 17 20-TRIONE
17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
17ALPHA,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE
17ALPHA-HYDROXY-11-DEHYDROCORTICOSTERONE
17-HYDROXY-11-DEHYDROCORTICOSTERONE
4-PREGEN-17A,21-DIOL-3,11,20-TRIONE
4-PREGNEN-17,21-DIOL-3,11,20-TRIONE
4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE
4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
CORTISONE
CORTONE
DELTA4-PREGNENE-17, 21-DIOL-3, 11, 20-TRIONE
DELTA4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
DELTA-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
KENDALL'S CMPD ''E''
KENDALL'S COMPOUND E
KENDALL'S COMPOUND 'E'
KENDALL'S ''E''
REICHSTEIN'S COMPOUND ''FA''
所屬類別
生物化學(xué)品: 生化試劑: 激素

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶性粉末。Mp220-224℃(部分分解),比旋光度[α]25D+209°(1.2%,95%乙醇)、[α]25546+269°(0.125%,苯)。溶于甲醇、乙醇、丙酮;微溶于乙醚、氯仿和苯;難溶于水,水溶液呈中性。在濃硫酸中呈橙紅色,并顯綠色熒光。
熔點(diǎn)223-228 °C (dec.)(lit.)
比旋光度D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
沸點(diǎn)412.46°C (rough estimate)
密度1.28±0.1 g/cm3 (20 ºC 760 Torr)
折射率210 ° (C=1, EtOH)
閃點(diǎn)9℃
儲(chǔ)存條件-20°C冷凍
溶解度Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Ethanol (Slightly, Heated)
酸度系數(shù)(pKa)12.37±0.60(Predicted)
形態(tài)固體
顏色白色至淺米色
水溶解性229.9mg/L(25 ºC)
Merck2539
LogP1.470
CAS 數(shù)據(jù)庫53-06-5(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H225-H301+H311+H331-H370
危險(xiǎn)品標(biāo)志F,T,Xn
危險(xiǎn)類別碼11-23/24/25-39/23/24/25-63
安全說明S22-S24/25
危險(xiǎn)品運(yùn)輸編號(hào)UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS號(hào)GM9020000
海關(guān)編碼2937210000

應(yīng)用領(lǐng)域

用途一
生化研究;皮質(zhì)激素類藥物,具有抗炎、抗過敏等作用。
參考質(zhì)量標(biāo)準(zhǔn)
mp215-225℃;比旋光度+207°;最大吸收波長238nm。

制備方法

方法一
以醋酸孕甾雙烯醇酮為原料,依次經(jīng)過氧化氫氧化、沃氏氧化、黑根菌生物氧化、鉻酐氧化得11-酮基-16,17α環(huán)氧黃體酮,經(jīng)氫溴酸開環(huán),氫化脫溴得粗品,再重結(jié)晶制得。

常見問題列表

應(yīng)用

可的松主要用于腎上腺皮質(zhì)功能減退癥的替代治療,但現(xiàn)在氫化可的松已優(yōu)先用于此癥。因?yàn)榭傻乃杀旧頍o活性,必需先在肝內(nèi)轉(zhuǎn)化成氫化可的松,某些肝臟疾病將影響其作用的可靠性。

生物活性
Cortisone是一種孕烷甾類激素,是身體應(yīng)對壓力應(yīng)激時(shí)釋放的主要物質(zhì)。它能抑制免疫系統(tǒng),從而減少炎癥反應(yīng)和炎性疼痛、傷處腫脹。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).

體內(nèi)研究

Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.

Animal Model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion
Dosage: 2 mg/kg
Administration: Intramuscular injection on alternate days for 2 months
Result: Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.

知名試劑公司產(chǎn)品信息

可的松價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/11XW00530652可的松
cortisone 、17-hydroxy-11-dehydrocorticosterone; 17α,21-dihydroxy-4-pregnene-3,11,20-trione; 11-dehydro-17-hydroxycorticosterone
53-06-55G1893元
2024/11/0846052可的松
Cortisone, 98%
53-06-5250mg305元
2024/11/0846052可的松
Cortisone, 98%
53-06-51g401元
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