1722-62-9
中文名稱
鹽酸甲哌卡因
英文名稱
Mepivacaine hydrochloride
CAS
1722-62-9
EINECS 編號
217-023-9
分子式
C15H22N2O
MDL 編號
MFCD00243006
分子量
246.35
MOL 文件
1722-62-9.mol
更新日期
2025/01/10 18:57:58
1722-62-9 結構式
基本信息
中文別名
N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺鹽酸鹽鹽酸甲哌卡因
低分子肝素
鹽酸卡波卡因
甲哌卡因鹽酸鹽
英文別名
1-methyl-2',6'-pipecoloxylidine hydrochloride1-METHYL-2',6'-PIPECOLOXYLIDINE HYDROCHLORIDE SALT
LABOTEST-BB LT00134661
MEPIVACAINE
MEPIVACAINE HCL
MEPIVACAINE HYDROCHLORIDE
n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
N-(2,6-DIMETHYLPHENYL)-1-METHYL-2-PIPERIDINECARBOXAMIDE HYDROCHLORIDE SALT
(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride
1-methyl-2’,6’-pipecoloxylididehydrochloride
6’-pipecoloxylidide,1-methyl-2monohydrochloride
carbocainehydrochloride
dl-1-methyl-2’,6’-pipecoloxylididehydrochloride
dl-mepivacainehydrochloride
n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride
MEPIVACAINE HYDROCHLORIDE, USP
Mepivacaine HCl USP
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride
2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI)
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)
所屬類別
原料藥：局部麻醉劑安全數據
警示詞危險
危險性描述H301-H336
危險品標志Xn
危險類別碼R22
安全說明S22-S24/25
危險品運輸編號UN 2811 6.1 / PGIII
RTECS號TK6475000
海關編碼29333990
毒性LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg)
1722-62-9(安全特性,毒性,儲運)
儲運特性
庫房低溫通風干燥毒性分級
中毒急性毒性
腹腔-小鼠 LD50: 117 毫克/公斤; 靜脈-小鼠 LD50: 35 毫克/公斤可燃性危險特性
熱分解排出有毒氮氧化物煙霧類別
有毒物質滅火劑
水, 二氧化碳, 泡沫, 干粉鹽酸甲哌卡因價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-B0517A | 鹽酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 500mg | 400元 |
| 2024/11/08 | HY-B0517A | 鹽酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 10mM * 1mLin Water | 440元 |
| 2024/11/08 | HY-B0517A | 鹽酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 1g | 600元 |
常見問題列表
生物活性
Mepivacaine 是一種叔胺，用作局部麻醉劑。體外研究
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.
體內研究
對馬的測試表明，與根據以前解剖的，乳膠注射后得到的假定相比，mepivacaine在相鄰關節(jié)結構間具有更大的擴撒，與關節(jié)造影研究形成對比。經歷膝關節(jié)鏡檢查患者中，與神經刺激相比較，超聲處理使1.5% mepivacaine阻斷坐骨神經所需的最低有效麻醉劑體積(MEAV50)減少37%。在犬齒和前臼齒中，lidocaine制劑與腎上腺素相比，3%mepivacaine的使用使麻醉時間間隔更短。