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ChemicalBook >> CAS DataBase List >> PF 543

PF 543

PF 543 price.
  • $25 - $2395.3
  • Product name: PF 543
  • CAS: 1415562-82-1
  • MF: C27H31NO4S
  • MW: 465.6
  • EINECS:
  • MDL Number:MFCD23098794
  • Synonyms:PF 543;PF543;PF-543;PF543/PF-543;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-2-pyrrolidineMethanol;2-PyrrolidineMethanol, 1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-, (2R)-;CS-745;PF-543(freebase)
24 prices
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  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX5812
  • Product descriptionPF543
  • Packaging10mg
  • Price$302
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3717
  • Product descriptionPF-543
  • Packaging10mM(in 1mL DMSO)
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3717
  • Product descriptionPF-543
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3717
  • Product descriptionPF-543
  • Packaging10mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3717
  • Product descriptionPF-543
  • Packaging50mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3717
  • Product descriptionPF-543
  • Packaging200mg
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146090
  • Product descriptionPF-543 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146090
  • Product descriptionPF-543 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146090
  • Product descriptionPF-543 >98%
  • Packaging1g
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging5mg
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging25mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM197335
  • Product description(R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98%
  • Packaging10mg
  • Price$241
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM197335
  • Product description(R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98%
  • Packaging50mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003574
  • Product descriptionPF-543 98+%
  • Packaging5mg
  • Price$135
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5812 PF543 10mg $302 2021-12-16 Buy
ApexBio Technology A3717 PF-543 10mM(in 1mL DMSO) $105 2021-12-16 Buy
ApexBio Technology A3717 PF-543 5mg $110 2021-12-16 Buy
ApexBio Technology A3717 PF-543 10mg $195 2021-12-16 Buy
ApexBio Technology A3717 PF-543 50mg $700 2021-12-16 Buy
ApexBio Technology A3717 PF-543 200mg $1800 2021-12-16 Buy
Biorbyt Ltd orb146090 PF-543 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb146090 PF-543 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb146090 PF-543 >98% 1g $2395.3 2021-12-16 Buy
Cayman Chemical 17034 PF-543 ≥98% 1mg $25 2021-12-16 Buy
Cayman Chemical 17034 PF-543 ≥98% 5mg $81 2021-12-16 Buy
Cayman Chemical 17034 PF-543 ≥98% 10mg $150 2021-12-16 Buy
Cayman Chemical 17034 PF-543 ≥98% 25mg $313 2021-12-16 Buy
Chemenu CM197335 (R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98% 10mg $241 2021-12-16 Buy
Chemenu CM197335 (R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98% 50mg $650 2021-12-16 Buy
Crysdot CD31003574 PF-543 98+% 5mg $135 2021-12-16 Buy

Properties

Boiling point :666.0±55.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.3 mg/mL in DMSO; insoluble in H2O; ≥51 mg/mL in EtOH with gentle warming and ultrasonic
pka :14.77±0.10(Predicted)
form :powder
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PF-543 is a potent inhibitor of sphingosine kinase 1 (SK1; IC50 = 2-3.6 nM) that less effectively inhibits SK2 (IC50 = 356 nM). It does not significantly block the activity of other protein and lipid kinases, or bind sphingosine-1-phosphate receptors, when tested at a concentration of 10 μM. PF-543 prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC50s = 8.4 and 27 nM, respectively). Through its effects on SK1, PF-543 prevents sickling, hemolysis, and inflammation in sickling cell disease transgenic mice. Unlike inhibitors that are selective for SK2, PF-543 does not impair DNA synthesis in human pulmonary arterial smooth muscle cells.

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