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ChemicalBook >> CAS DataBase List >> ABT 737

ABT 737

ABT 737 price.
  • $27 - $2691.1
  • Product name: ABT 737
  • CAS: 852808-04-9
  • MF: C42H45ClN6O5S2
  • MW: 813.43
  • EINECS:
  • MDL Number:MFCD12756212
  • Synonyms:4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide;ABT 737;4-{4-[(4'-Chlorobiphenyl-2-yl)Methyl]piperazin-1-yl}-N-[(4-{[(2R)-4-(diMethylaMino)-1-(phenylsulfanyl)butan-2-yl]aMino}-3-nitrophenyl)sulfonyl]benzaMide;(R)-4-(4-((4'-chlorobiphenyl-2-yl)Methyl)piperazin-1-yl)-N-(4-(4-(diMethylaMino)-1-(phenylthio)butan-2-ylaMino)-3-nitrophenylsulfonyl)benzaMide;BenzaMide, 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)Methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(diMethylaMino)-1-[(phenylthio)Methyl]propyl]aMino]-3-nitrophenyl]sulfonyl]-;4-{4-[(4'-Chlorobiphenyl-2-yl)Methyl]piperazin-1-yl}-N-[(4-{[(2R)-4-(diMethylaMino)-1-;ABT737/ABT-737;4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide ABT-737
44 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 1mg
  • 1unit
  • 2.5MG
  • 5mg
  • 10mg
  • 10
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 50
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1001-M005
  • Product descriptionABT-737 ≥95%
  • Packaging5mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1001
  • Product descriptionBcl-2InhibitorVI,ABT-737
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7536
  • Product descriptionABT-737
  • Packaging100mg
  • Price$641
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1001
  • Product descriptionBcl-2InhibitorVI,ABT-737
  • Packaging100mg
  • Price$925
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging1mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging5mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging10mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging50mg
  • Price$232
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging100mg
  • Price$322
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging250mg
  • Price$608
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA821402
  • Product descriptionABT-737 98+%
  • Packaging1g
  • Price$1536
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005463
  • Product descriptionABT-737 95.00%
  • Packaging1MG
  • Price$179.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005463
  • Product descriptionABT-737 95.00%
  • Packaging2.5MG
  • Price$742.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005463
  • Product descriptionABT-737 95.00%
  • Packaging25MG
  • Price$2194.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8193
  • Product descriptionABT-737
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8193
  • Product descriptionABT-737
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1001-M005 ABT-737 ≥95% 5mg $97 2021-12-16 Buy
AK Scientific SYN1001 Bcl-2InhibitorVI,ABT-737 10mg $160 2021-12-16 Buy
AK Scientific X7536 ABT-737 100mg $641 2021-12-16 Buy
AK Scientific SYN1001 Bcl-2InhibitorVI,ABT-737 100mg $925 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 1mg $27 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 5mg $46 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 10mg $78 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 50mg $232 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 100mg $322 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 250mg $608 2021-12-16 Buy
Ambeed A821402 ABT-737 98+% 1g $1536 2021-12-16 Buy
American Custom Chemicals Corporation INB0005463 ABT-737 95.00% 1MG $179.55 2021-12-16 Buy
American Custom Chemicals Corporation INB0005463 ABT-737 95.00% 2.5MG $742.5 2021-12-16 Buy
American Custom Chemicals Corporation INB0005463 ABT-737 95.00% 25MG $2194.5 2021-12-16 Buy
ApexBio Technology A8193 ABT-737 1unit $28 2021-12-16 Buy
ApexBio Technology A8193 ABT-737 5mg $50 2021-12-16 Buy

Properties

Melting point :152-154°C
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form :Yellow solid
pka :4.65±0.10(Predicted)
color :Light Yellow to Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with potential pro-apoptotic and antineoplastic activities,  with an affinity two to three orders of magnitude more potent than previously reported compounds but no affinity towards less homologous proteins, such as BCL-B, MCL-1, and A1. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki <1 nM) and also shows a very high specificity over Mcl-1 and A1.
ABT-737 induces apoptosis in MM cells, including those resistant to conventional therapy. Importantly, ABT-737 decreases the viability of bortezomib-, dexamethasone-(Dex) and thalidomide-refractory patient MM cells. Additionally, ABT-737 abrogates MM cell growth triggered by interleukin-6 or insulin-like growth factor-1. Mechanistic studies show that ABT-737-induced apoptosis is associated with activation of caspase-8, caspase-9 and caspase-3, followed by poly(ADP-ribose) polymerase cleavage.
ABT-737 has shown single-agent activity against lymphoma and small-cell lung cancer as well as substantial antimyeloma activity both in vitro and in vivo. In recent studies, acute myeloid leukemia blast, origenitor, and stem cells are effectively killed by ABT-737 with normal hematopoietic cells intact. The disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway could also be induced by ABT-737.

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