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ChemicalBook >> CAS DataBase List >> 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid price.
  • $32 - $950
  • Product name: 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • CAS: 1467057-23-3
  • MF: C19H16ClNO3
  • MW: 341.79
  • EINECS:
  • MDL Number:MFCD29917835
  • Synonyms:6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;PF-06409577;CS-2760;PF-06409577;PF 06409577;PF06409577;EOS-61684;PF 06409577;PF06409577;PF 6409577;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-
20 prices
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Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 5mg
  • 10
  • 1mg
  • 50
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number5408DV
  • Product description6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5408DV
  • Product description6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBP166583
  • Product descriptionPF 06409577 NEW
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBP166583
  • Product descriptionPF 06409577 NEW
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27366
  • Product descriptionPF-06409577
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27366
  • Product descriptionPF-06409577
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27366
  • Product descriptionPF-06409577
  • Packaging10mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27366
  • Product descriptionPF-06409577
  • Packaging25mg
  • Price$343
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-8071
  • Product descriptionPF-06409577 99.07%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-8071
  • Product descriptionPF-06409577 99.07%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-8071
  • Product descriptionPF-06409577 99.07%
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-8071
  • Product descriptionPF-06409577 99.07%
  • Packaging50mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-8071
  • Product descriptionPF-06409577 99.07%
  • Packaging100mg
  • Price$810
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC11466
  • Product descriptionPF-06409577 >98%
  • Packaging250mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0319
  • Product descriptionPF-06409577 ≥98% (HPLC)
  • Packaging25MG
  • Price$424
  • Updated2023-06-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0319
  • Product descriptionPF-06409577 ≥98% (HPLC)
  • Packaging5MG
  • Price$105
  • Updated2023-06-20
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5408DV 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 10mg $218 2021-12-16 Buy
AK Scientific 5408DV 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid 50mg $640 2021-12-16 Buy
Biosynth Carbosynth BP166583 PF 06409577 NEW 10mg $125 2021-12-16 Buy
Biosynth Carbosynth BP166583 PF 06409577 NEW 50mg $437.5 2021-12-16 Buy
Cayman Chemical 27366 PF-06409577 1mg $32 2024-03-01 Buy
Cayman Chemical 27366 PF-06409577 5mg $100 2024-03-01 Buy
Cayman Chemical 27366 PF-06409577 10mg $169 2024-03-01 Buy
Cayman Chemical 27366 PF-06409577 25mg $343 2024-03-01 Buy
ChemScene CS-8071 PF-06409577 99.07% 5mg $70 2021-12-16 Buy
ChemScene CS-8071 PF-06409577 99.07% 10mg $120 2021-12-16 Buy
ChemScene CS-8071 PF-06409577 99.07% 25mg $280 2021-12-16 Buy
ChemScene CS-8071 PF-06409577 99.07% 50mg $480 2021-12-16 Buy
ChemScene CS-8071 PF-06409577 99.07% 100mg $810 2021-12-16 Buy
DC Chemicals DC11466 PF-06409577 >98% 250mg $950 2021-12-16 Buy
Sigma-Aldrich PZ0319 PF-06409577 ≥98% (HPLC) 25MG $424 2023-06-20 Buy
Sigma-Aldrich PZ0319 PF-06409577 ≥98% (HPLC) 5MG $105 2023-06-20 Buy

Properties

Boiling point :610.9±55.0 °C(Predicted)
Density :1.468±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble
pka :3.60±0.30(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.