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ChemicalBook >> CAS DataBase List >> 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione price.
  • $26 - $1450
  • Product name: 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
  • CAS: 198474-05-4
  • MF: C12H9FN2O2
  • MW: 232.21
  • EINECS:
  • MDL Number:MFCD25121820
  • Synonyms:2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-;3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione;3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione;PF-06840003;PF 06840003;PF-06840003;EOS200271;PF-06840003 (racemate);3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione
25 prices
Selected condition：
Brand
  • Abosyn
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAbosyn
  • Product number21-1093
  • Product description3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione 95%-98%
  • Packaging1g
  • Price$525
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number7203DA
  • Product description3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
  • Packaging50mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA196131
  • Product descriptionPF-06840003 98%
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0621043
  • Product description3-(5-FLUORO-1H-INDOL-3-YL)PYRROLIDINE-2,5-DIONE 95.00%
  • Packaging5MG
  • Price$454.59
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon3325
  • Product descriptionPF-06840003-EOS200271 98%
  • Packaging10mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBP168137
  • Product descriptionPF 06840003
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBP168137
  • Product descriptionPF 06840003
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25003
  • Product descriptionEOS200271 ≥98%
  • Packaging25mg
  • Price$90
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25003
  • Product descriptionEOS200271 ≥98%
  • Packaging10mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25003
  • Product descriptionEOS200271 ≥98%
  • Packaging1mg
  • Price$39
  • Updated2023-01-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number25003
  • Product descriptionEOS200271 ≥98%
  • Packaging5mg
  • Price$26
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM250991
  • Product description3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione 95%
  • Packaging100mg
  • Price$987
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6186
  • Product descriptionPF-06840003 99.79%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6186
  • Product descriptionPF-06840003 99.79%
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6186
  • Product descriptionPF-06840003 99.79%
  • Packaging50mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6186
  • Product descriptionPF-06840003 99.79%
  • Packaging100mg
  • Price$350
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 21-1093 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione 95%-98% 1g $525 2021-12-16 Buy
AK Scientific 7203DA 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione 50mg $173 2021-12-16 Buy
Ambeed A196131 PF-06840003 98% 10mg $95 2021-12-16 Buy
American Custom Chemicals Corporation HCH0621043 3-(5-FLUORO-1H-INDOL-3-YL)PYRROLIDINE-2,5-DIONE 95.00% 5MG $454.59 2021-12-16 Buy
Axon Medchem Axon3325 PF-06840003-EOS200271 98% 10mg $77 2021-12-16 Buy
Biosynth Carbosynth BP168137 PF 06840003 10mg $175 2021-12-16 Buy
Biosynth Carbosynth BP168137 PF 06840003 50mg $612.5 2021-12-16 Buy
Cayman Chemical 25003 EOS200271 ≥98% 25mg $90 2024-03-01 Buy
Cayman Chemical 25003 EOS200271 ≥98% 10mg $44 2024-03-01 Buy
Cayman Chemical 25003 EOS200271 ≥98% 1mg $39 2023-01-06 Buy
Cayman Chemical 25003 EOS200271 ≥98% 5mg $26 2024-03-01 Buy
Chemenu CM250991 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione 95% 100mg $987 2021-12-16 Buy
ChemScene CS-6186 PF-06840003 99.79% 5mg $70 2021-12-16 Buy
ChemScene CS-6186 PF-06840003 99.79% 10mg $100 2021-12-16 Buy
ChemScene CS-6186 PF-06840003 99.79% 50mg $220 2021-12-16 Buy
ChemScene CS-6186 PF-06840003 99.79% 100mg $350 2021-12-16 Buy

Properties

Melting point :190-195 °C
Boiling point :533.2±50.0 °C(Predicted)
Density :1.464±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :9.13±0.50(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3

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