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ChemicalBook >> CAS DataBase List >> PF 573228

PF 573228

PF 573228 price.
  • $23 - $2691.1
  • Product name: PF 573228
  • CAS: 869288-64-2
  • MF: C22H20F3N5O3S
  • MW: 491.49
  • EINECS:
  • MDL Number:MFCD11519967
  • Synonyms:PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone;6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one;6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one;2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-;Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228;PF 573228 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one;PF-228
41 prices
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Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 10
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  • 1mg
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  • 50
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  • 1g
  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging1mg
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging5mg
  • Price$47
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging10mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging50mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging100mg
  • Price$314
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging250mg
  • Price$609
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA230913
  • Product description6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+%
  • Packaging1g
  • Price$1570
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001081
  • Product descriptionPF 573228 95.00%
  • Packaging1MG
  • Price$135.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001081
  • Product descriptionPF 573228 95.00%
  • Packaging10MG
  • Price$727.65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001081
  • Product descriptionPF 573228 95.00%
  • Packaging100MG
  • Price$1824.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1523
  • Product descriptionPF-573228
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1523
  • Product descriptionPF-573228
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1523
  • Product descriptionPF-573228
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60223
  • Product descriptionPF-573228
  • Packaging10mg
  • Price$188
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1623
  • Product descriptionPF573228 99%
  • Packaging5mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146159
  • Product descriptionPF573228 >99%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 1mg $23 2021-12-16 Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 5mg $47 2021-12-16 Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 10mg $67 2021-12-16 Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 50mg $210 2021-12-16 Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 100mg $314 2021-12-16 Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 250mg $609 2021-12-16 Buy
Ambeed A230913 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one 98+% 1g $1570 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001081 PF 573228 95.00% 1MG $135.45 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001081 PF 573228 95.00% 10MG $727.65 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001081 PF 573228 95.00% 100MG $1824.9 2021-12-16 Buy
ApexBio Technology B1523 PF-573228 1unit $28 2021-12-16 Buy
ApexBio Technology B1523 PF-573228 10mg $90 2021-12-16 Buy
ApexBio Technology B1523 PF-573228 50mg $350 2021-12-16 Buy
Arctom CFN60223 PF-573228 10mg $188 2021-12-16 Buy
Axon Medchem Axon1623 PF573228 99% 5mg $104.5 2021-12-16 Buy
Biorbyt Ltd orb146159 PF573228 >99% 100mg $838.1 2021-12-16 Buy

Properties

Melting point :>242°C (dec.)
Density :1.459
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :14.30±0.20(Predicted)
color :white to off-white
InChIKey :HESLKTSGTIBHJU-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

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