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ChemicalBook >> CAS DataBase List >> 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester price.
  • $48 - $2691.1
  • Product name: 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
  • CAS: 1144035-53-9
  • MF: C22H21Cl2N3O5
  • MW: 478.33
  • EINECS:
  • MDL Number:MFCD20527274
  • Synonyms:PF 8380;3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate;4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester;3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carboxyl;PF-8380, ATX Inhibitor;3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-ca.;3,5-dichlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-2-carboxylate;4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic acid (3,5-dichlorophenyl)methyl ester
30 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5
  • 5mg
  • 1mg
  • 25
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX5984
  • Product descriptionPF-8380
  • Packaging5mg
  • Price$127
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0002662
  • Product description3,5-DICHLOROBENZYL-4-(3-OXO-3-(2-OXO-2,3-DIHYDROBENZO[D]OXAZOL-6-YL)PROPYL)PIPERAZINE-1-CARBOXYLATE 95.00%
  • Packaging5MG
  • Price$205.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181098
  • Product descriptionPF-8380 >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181098
  • Product descriptionPF-8380 >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181098
  • Product descriptionPF-8380 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP157997
  • Product descriptionPF 8380
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number12018
  • Product descriptionPF-8380 ≥95%
  • Packaging1mg
  • Price$48
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number12018
  • Product descriptionPF-8380 ≥95%
  • Packaging5mg
  • Price$131
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number12018
  • Product descriptionPF-8380 ≥95%
  • Packaging10mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number12018
  • Product descriptionPF-8380 ≥95%
  • Packaging25mg
  • Price$420
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM160710
  • Product description3,5-Dichlorobenzyl4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carboxylate 98%
  • Packaging100mg
  • Price$589
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0591
  • Product descriptionPF-8380 98.95%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0591
  • Product descriptionPF-8380 98.95%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0591
  • Product descriptionPF-8380 98.95%
  • Packaging50mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0591
  • Product descriptionPF-8380 98.95%
  • Packaging100mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004478
  • Product descriptionPF-8380 98+%
  • Packaging50mg
  • Price$275
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5984 PF-8380 5mg $127 2021-12-16 Buy
American Custom Chemicals Corporation INB0002662 3,5-DICHLOROBENZYL-4-(3-OXO-3-(2-OXO-2,3-DIHYDROBENZO[D]OXAZOL-6-YL)PROPYL)PIPERAZINE-1-CARBOXYLATE 95.00% 5MG $205.7 2021-12-16 Buy
Biorbyt Ltd orb181098 PF-8380 >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb181098 PF-8380 >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb181098 PF-8380 >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FP157997 PF 8380 10mg $125 2021-12-16 Buy
Cayman Chemical 12018 PF-8380 ≥95% 1mg $48 2024-03-01 Buy
Cayman Chemical 12018 PF-8380 ≥95% 5mg $131 2024-03-01 Buy
Cayman Chemical 12018 PF-8380 ≥95% 10mg $169 2024-03-01 Buy
Cayman Chemical 12018 PF-8380 ≥95% 25mg $420 2024-03-01 Buy
Chemenu CM160710 3,5-Dichlorobenzyl4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carboxylate 98% 100mg $589 2021-12-16 Buy
ChemScene CS-0591 PF-8380 98.95% 5mg $60 2021-12-16 Buy
ChemScene CS-0591 PF-8380 98.95% 10mg $90 2021-12-16 Buy
ChemScene CS-0591 PF-8380 98.95% 50mg $330 2021-12-16 Buy
ChemScene CS-0591 PF-8380 98.95% 100mg $590 2021-12-16 Buy
Crysdot CD31004478 PF-8380 98+% 50mg $275 2021-12-16 Buy

Properties

Density :1.419
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
form :Tan powder
pka :8.74±0.70(Predicted)
color :white to beige
InChIKey :JMSUDQYHPSNBSN-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an in vitro enzyme assay). PF-8380 (30 mg/kg) reduces LPA production by >95% following carrageenan-induced inflammation in rats and inhibits autotaxin activity in human whole blood (IC50 = 101 nM).

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