Everolimus
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- $8 - $2160
- Product name: Everolimus
- CAS: 159351-69-6
- MF: C53H83NO14
- MW: 958.22
- EINECS:621-003-9
- MDL Number:MFCD00929329
- Synonyms:Rapamycin, 42-O-(2-hydroxyethyl)-;Everolimus;Certican;CERTICAN(R);EveroliMus(RAD-001);(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-Methoxycyclohexyl]propan-2-yl]-19,30-diMethoxy-15,17,21,23,29,35-hexaMethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,2;EveroliMus API;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv
79 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- IsoSciences
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- Y0002061
- 20mg
- Y0002048
- 200mg
- 10
- 300mg
- 500mg
- 1mL
- Y0002063
- 10mM(in 1mL DMSO)
- 1mg
- 1unit
- 5mg
- 10mg
- 25mg
- 50MG
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberCDX-E0074-M250
- Product descriptionEverolimus ≥99%(HPLC)
- Packaging250mg
- Price$882
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV2036
- Product descriptionEverolimus
- Packaging25mg
- Price$192
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ60139
- Product descriptionEverolimus
- Packaging5mg
- Price$152.65
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ60139
- Product descriptionEverolimus
- Packaging10mg
- Price$221.65
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ60139
- Product descriptionEverolimus
- Packaging25mg
- Price$380.65
- Updated2024-03-01
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging1mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging5mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging10mg
- Price$24
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging25mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging100mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging250mg
- Price$146
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA116645
- Product descriptionEverolimus 98%
- Packaging1g
- Price$392
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002667
- Product descriptionEVEROLIMUS 95.00%
- Packaging5MG
- Price$614.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002667
- Product descriptionEVEROLIMUS 95.00%
- Packaging50MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8169
- Product descriptionEverolimus(RAD001)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8169
- Product descriptionEverolimus(RAD001)
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | CDX-E0074-M250 | Everolimus ≥99%(HPLC) | 250mg | $882 | 2021-12-16 | Buy |
| AK Scientific | V2036 | Everolimus | 25mg | $192 | 2021-12-16 | Buy |
| Alfa Aesar | J60139 | Everolimus | 5mg | $152.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60139 | Everolimus | 10mg | $221.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60139 | Everolimus | 25mg | $380.65 | 2024-03-01 | Buy |
| Ambeed | A116645 | Everolimus 98% | 1mg | $8 | 2021-12-16 | Buy |
| Ambeed | A116645 | Everolimus 98% | 5mg | $16 | 2021-12-16 | Buy |
| Ambeed | A116645 | Everolimus 98% | 10mg | $24 | 2021-12-16 | Buy |
| Ambeed | A116645 | Everolimus 98% | 25mg | $40 | 2021-12-16 | Buy |
| Ambeed | A116645 | Everolimus 98% | 100mg | $88 | 2021-12-16 | Buy |
| Ambeed | A116645 | Everolimus 98% | 250mg | $146 | 2021-12-16 | Buy |
| Ambeed | A116645 | Everolimus 98% | 1g | $392 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002667 | EVEROLIMUS 95.00% | 5MG | $614.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002667 | EVEROLIMUS 95.00% | 50MG | $1871.1 | 2021-12-16 | Buy |
| ApexBio Technology | A8169 | Everolimus(RAD001) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A8169 | Everolimus(RAD001) | 10mg | $70 | 2021-12-16 | Buy |
Properties
Melting point :NA
Boiling point :998.7±75.0 °C(Predicted)
Density :1.18±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :-20°C
solubility :Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
form :solid
pka :10.40±0.70(Predicted)
color :White
Water Solubility :Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability :Hygroscopic
InChIKey :HKVAMNSJSFKALM-GKUWKFKPSA-N
Boiling point :998.7±75.0 °C(Predicted)
Density :1.18±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :-20°C
solubility :Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
form :solid
pka :10.40±0.70(Predicted)
color :White
Water Solubility :Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability :Hygroscopic
InChIKey :HKVAMNSJSFKALM-GKUWKFKPSA-N
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Everolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor.In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.
Everolimus is a biological therapy treatment for
Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane
Advanced kidney cancer that has come back either during or after treatment.
Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease).
Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
AFINE CHEMICALS LIMITED
Seasons Biotechnology Co., Ltd.
BOC Sciences
Capot Chemical Co.,Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
