Argatroban
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Argatroban Eigenschaften
- Schmelzpunkt:
- 176-180°
- alpha
- D27 +76.1° (c = 1 in 0.2N HCl)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- Solid
- Farbe
- white to off-white
- Merck
- 14,779
- CAS Datenbank
- 141396-28-3(CAS DataBase Reference)
Sicherheit
WGK Germany | 3 | ||
---|---|---|---|
RTECS-Nr. | TM6126610 | ||
HS Code | 29350090 | ||
Toxizit?t | mouse,LD50,intraperitoneal,475mg/kg (475mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABLOOD: NORMOCYTIC ANEMIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
Argatroban Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Argatroban monohydrate has been used as a thrombin-selective inhibitor in the thrombin assay of platelet poor plasma samples. It may be used as a standard in gradient reversed-phase liquid chromatography coupled with high-resolution multistage mass spectrometry (LC/HR-MSn) for photoproducts fragmentation analysis and as a thrombin inhibitor competitive assay with fullerene-based C60 nanoparticle (NPs).Allgemeine Beschreibung
Argatroban anticoagulant is synthesized from L-arginine and photodegrades under light exposure.Enzyminhibitor
This anticoagulant (FW = 508.64 g/mol; CAS 74863-84-6), also named (2R,4R) -4-methyl-1-N2-[ (3-methyl-1,2,3,4-tetrahydro-8-quinolilyl) sulfon- yl]-L-arginyl-2-piperidine carboxylic acid, Novastan?, and MD-805, is a direct thrombin inhibitor (1-11) that is an effective treatment for heparin- induced thrombocytopenia (HIT), an immunoglobulin-mediated adverse drug reaction characterized by platelet activation, thrombocytopenia, and a high risk of thrombotic complications among patients who are receiving or have recently received heparin. HIT is an autoimmune-like disorder, with the target antigen a multimolecular complex of the “self” protein, Platelet Factor-4, and heparin. Continued use of heparin is ill-advised and dangerous. Argatroban is also indicated for the treatment of heparin- induced thrombocytopenia and thrombosis syndrome (HITTS), an immune- mediated response to the administration of heparin that results in life- threatening thrombosis. Argatroban is one of four FDA-approved parenteral direct thrombin inhibitors, the others being lepirudin, desirudin, and bivalirudin. Argatroban is metabolized in the liver (t1/2 = ~50 min). Other DTI’s include recombinant hirudins, bivalirudin, and ximelagatran, either alone or in combination with melagatran. Argatroban is a significantly weaker inhibitor of trypsin, K = 4.3 μM, plasmin (K = ii 800 μM), coagulation factor Xa, and plasma kallikrein (Ki = 2 mM). Commercial sources often supply a mixture of 21 (R) and 21 (S) Diastereoisomers. The latter is more potent.Argatroban Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Chloroformate
3-Methyl-8-quinolinesulphonyl chloride
Palladium
N,N-Diethylethanamin
Isobutylphenylacetat
Isobutylchlorformiat
Downstream Produkte
Argatroban Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 296)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 474 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32956 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 |
sales@amoychem.com | China | 6383 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
141396-28-3()Verwandte Suche:
Aminocapronsure
ALTRENOGEST
Chinhydron
1,2,3,4-Tetrahydroisochinolin
Glycin
Ethoxychin
Isochinolin
Trometamol
Quinclorac
2-Aminophenol
Pyridin-2,3-dicarbonsure
(R)-Piperidin-2-carbonsure
1,2,3,4-Tetrahydrochinolin
Schwefelsaeurediamid
Arecolinhydrobromid
AMINO ACIDS
- Argatroban (hydrate)
- Argatroban (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
- Argatroban (350 mg)
- (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid hydrate
- (2r,4r)-1-[(2s)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
- GN1600
- (2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
- Argatroban API
- (2R,4R)-4-Methyl-1-[Nalpha-[(3-Methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid
- Argatroban 1-hydrate
- AG, SAJ
- Agatroban monohydrate
- CS-1966
- Acova monohydrate
- Argipidine monohydrate
- ARGIPIDINE MONOHYDRATE; ACOVA MONOHYDRATE
- (2r,4r)-1-((2s)-5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-2-piperidinecarboxylic acid
- Argatroban Monohydrate>
- Argatroban hydrate (MD805
- (2R,4R)-4-Methyl-1-[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-q...
- US-DMF:035491
- (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid
- Argatroban (1042408)
- (2r,4r)-4-methyl-1-[n-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl]-2-piperidinecarboxylic acid
- Argatroban Monohydrate
- Benzenesulfonicacid,8-(acetylamino)-,hydrazide
- (2R,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid hydrate
- API Cas:141396-28-3
- (2R,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid hydrate? (Argatroban Impurity)
- 141396-28-3
- C23H36N6O5SH2O