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Aminocapronsure

6-Aminocaproic acid Struktur
60-32-2
CAS-Nr.
60-32-2
Bezeichnung:
Aminocapronsure
Englisch Name:
6-Aminocaproic acid
Synonyma:
6-AMINOHEXANOIC ACID;ACS;Aminocaproic;6-aminohexanoate;EACA;Amicar;H-ACP-OH;Hepin;177 J.D;aminocaproic acid,EACA
CBNumber:
CB5223888
Summenformel:
C6H13NO2
Molgewicht:
131.17
MOL-Datei:
60-32-2.mol

Aminocapronsure Eigenschaften

Schmelzpunkt:
207-209 °C (dec.) (lit.)
Siedepunkt:
242.49°C (rough estimate)
Dichte
1.042 g/cm3
Dampfdruck
<0.1 hPa (20 °C)
Brechungsindex
1.4870 (estimate)
Flammpunkt:
207-209°C
storage temp. 
Store below +30°C.
L?slichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
pka
4.373(at 25℃)
Farbe
white
Geruch (Odor)
Odorless
PH
7.0-7.5 (50g/l, H2O, 20℃)
Wasserl?slichkeit
SOLUBLE
Merck 
14,432
BRN 
906872
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
LogP
0.027 (est)
CAS Datenbank
60-32-2(CAS DataBase Reference)
NIST chemische Informationen
Hexanoic acid, 6-amino-(60-32-2)
EPA chemische Informationen
Hexanoic acid, 6-amino- (60-32-2)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  2
RTECS-Nr. MO6300000
TSCA  Yes
HS Code  29224995
Giftige Stoffe Daten 60-32-2(Hazardous Substances Data)
Toxizit?t LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warnung P264, P305+P351+P338,P337+P313
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Aminocapronsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform.

synthetische

6-aminocaproic acid is obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide.

Application

6-Aminohexanoic acid was used as a biochemical reagent. It is also used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology.
6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect.

Definition

ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion.

Allgemeine Beschreibung

6-Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. It also is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity.

Mechanism of action

Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.

Sicherheitsprofil

Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.

Aminocapronsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Aminocapronsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 713)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co.,Ltd
+8618007136271
hk@fortunachem.com China 5998 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Yancheng Green Chemicals Co.,Ltd
+undefined-86-25-86655873
info@royal-chem.com China 114 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Sichuan HongRi Pharma-Tech Co.,Ltd
+86-028-64841719 +8617390183901
daisy@enlaibio.com China 1106 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60

60-32-2(Aminocapronsure)Verwandte Suche:


  • 177 J.D.
  • 177j.d.
  • 177jd
  • 6-amino-hexanoicaci
  • Acepramin
  • Acepramine
  • Afibrin
  • Amikar
  • Aminokapron
  • Atsemin
  • Caplamin
  • Capracid
  • capralense
  • Capramol
  • Capranol
  • Caprocid
  • Caprolisin
  • CL 10304
  • cl10304
  • CY 116
  • cy116
  • eacakabi
  • EACS
  • e-aminocaproicacid
  • Epsamon
  • Epsicapron
  • Epsikapron
  • Epsilcapramin
  • epsilon S
  • epsilon-Amino-n-hexanoic acid
  • EPSILON-AMINO HEXANOIC ACID
  • EPSILON-AMINO-N-CAPROIC ACID
  • H-E-ACP-OH
  • H-EPSILON-ACP-OH
  • H-EPSILON-AHX-OH
  • H-EPSILON-AMINOCAPROIC ACID
  • H-AHX(6)-OH
  • H-6-AHX-OH
  • H-ACP(6)-OH
  • NH2-(CH2)5-COOH
  • OMEGA-AMINOCAPROIC ACID
  • ETA-AMINOCAPROIC ACID
  • 6-AMINOCAPROIC ACID SIGMAULTRA
  • 6-Aminohexanoic acid 1 M Solution
  • 6-AminocaproicAcid,>99%
  • H-6-Aca-OH~epsilon-Aminocaproic acid~6-Aminohexanoic acid~EACA
  • H-EAhx-OH
  • 6-AMinocaproic acid, 99+% 500GR
  • AMinocaproic-d6 Acidd6
  • A 14719
  • Acikaprin
  • NSC 212532
  • NSC 400230
  • ε-AMino-n-hexanoic Acid
  • 6-AMINOHEXANOIC ACID FOR SYNTHESIS
  • AMinocaproic acid (AMicar)
  • 6-AMinocaporic Acid
  • Additive Screening Solution 32/Fluka kit no 78374
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