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6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1)

Ciclopirox ethanolamine Struktur
41621-49-2
CAS-Nr.
41621-49-2
Bezeichnung:
6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1)
Englisch Name:
Ciclopirox ethanolamine
Synonyma:
CICLOPIROXOLAMINE;Cyclopirox olamine;terit;Ciclobiroxolamine;6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE, 2-AMINO-ETHANOL;6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridinoncompd.with2-aminoethanol;2-aminoethanolcompd.with6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridinone(;lorpox;hoe296;Cicloche
CBNumber:
CB0673864
Summenformel:
C14H24N2O3
Molgewicht:
268.36
MOL-Datei:
41621-49-2.mol

6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1) Eigenschaften

Schmelzpunkt:
144 C
Dichte
0.41g/cm3 at 25℃
Dampfdruck
0-0Pa at 20-50℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
L?slichkeit
Sparingly soluble in water, very soluble in ethanol (96 per cent) and in methylene chloride, slightly soluble in ethyl acetate, practically insoluble in cyclohexane.
Aggregatzustand
Solid
Farbe
White to Off-White
LogP
0.52
CAS Datenbank
41621-49-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn
R-S?tze: 36/37/38-42/43-20/22
S-S?tze: 26-36-22
WGK Germany  2
RTECS-Nr. UU7785500
HS Code  2933790002
Toxizit?t LD50 in mice, rats (mg/kg): 2898, 3290 orally (Alpermann, Schutz)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.

Chemische Eigenschaften

White or pale yellow, crystalline powder.

Verwenden

Ciclopirox ethanolamine is a broad spectrum antimycotic agent with some antibacterial activity.

Definition

ChEBI: The ethanolamine salt of ciclopirox. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin an nail infections.

Indications

Ciclopirox olamine (Loprox, Penlac) is a synthetic, broad-spectrum hydroxypyridone antifungal agent. It is chemically unrelated to the imidazoles or any other antifungal agent currently available in the United States. It appears to act through intracellular depletion of substrates and/or ions principally by inhibition of transmembrane transport of these substances. It is active against dermatophytes, yeast, and Pityrosporum orbiculare. It also demonstrates activity against Trichomonas vaginalis, some mycoplasma, and some gram-positive and gram-negative bacteria.

Clinical Use

6-Cyclohexyl-1-hydroxyl-4-methyl-2(1H)-pyridinoneethanolamine salt (Loprox) is a broad-spectrum antifungalagent intended only for topical use. It is active against dermatophytesas well as pathogenic yeasts (C. albicans) thatare causative agents for superficial fungal infections.
Ciclopirox is considered an agent of choice in the treatmentof cutaneous candidiasis, tinea corporis, tinea cruris,tinea pedis, and tinea versicolor. It is a second-line agent forthe treatment of onychomycosis (ringworm of the nails).Loprox is formulated as a cream and a lotion, each containing1% of the water-soluble ethanolamine salt. Ciclopirox isbelieved to act on cell membranes of susceptible fungi atlow concentrations to block the transport of amino acids intothe cells. At higher concentrations, membrane integrity islost, and cellular constituents leak out.

Sicherheitsprofil

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic fumes ofNOx.

6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 410)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co
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sales@coreychem.com China 29880 58
APOLLO HEALTHCARE RESOURCES
+6596580999
sales@apollo-healthcare.com.sg Singapore 399 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
airuikechemical co., ltd.
+86-18353166132 +86-18353166132
sales02@airuikechemical.com China 983 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9080 55

41621-49-2(6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1))Verwandte Suche:


  • ciclopirox ethanolamine
  • lorpox
  • 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
  • 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-2[1H]-PYRIDONE ETHANOLAMINE SALT
  • 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-2(1H)-PYRIDONE ETHANOLAMMONIUM SALT
  • 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1h)-one 2-aminoethanol (1:1)
  • ciclopiroxy olamine
  • Cicloche
  • Micoxalamina
  • ethanolammonium salt
  • Ciclopirox Olamine (125 mg)
  • Ciclopirox ethanolam
  • Ciciopirox OlaMine
  • 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-, compd. with 2-aminoethanol (1:1)
  • Ciclopirox olamine, >=98%
  • 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridinonecompd.with2-aminoethanol(
  • 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridon,2-aminoethanol-salz
  • 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridone,2-aminoethanolsalt
  • batrafen
  • ciclopiroxethanolaminesalt(1:1)
  • ciclopiroxolamin
  • hoe296
  • C14H24N5O3
  • Ciclopirox Olamine Ointment
  • Ciclopirox olamine CRS
  • Ciclopirox ethanolamine Solution in Methanol, 1000 ug/ml
  • Ciclopirox ethanolamine USP/EP/BP
  • 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one 2-aminoethanol salt
  • Ciclopirox ethanolamine (HOE 296)
  • Ciclopirox Olamine (1134030)
  • CICLOPIROXOLAMINE
  • 2-aminoethanolcompd.with6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridinone(
  • 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridinoncompd.with2-aminoethanol
  • terit
  • Ciclobiroxolamine
  • 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE, 2-AMINO-ETHANOL
  • Cyclopirox olamine
  • 6-c yc loh e xyl-1-h yd roxy-4-me th ylpyri d i n-2(1h )-one a nd 2-a mi noe th a nol
  • 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one
  • 41621-49-2
  • C14H24N2O3
  • C12H17NO2C2H7NO
  • C12H17NO2xC2H7NO
  • Analytical Standards
  • Analytical Chromatography Product Catalog
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  • CI - CL
  • ZINC OMADINE
  • 41621-49-2
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