Ciclopirox
|
|
|
- CAS-Nr.
- 29342-05-0
- Bezeichnung:
- Ciclopirox
- Englisch Name:
- Ciclopirox
- Synonyma:
- Penlac;6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one;gopmx;geprox;Loprox;HOE296b;Mycoster;Brumixol;Dafnegin;Cidochem
- CBNumber:
- CB7673863
- Summenformel:
- C12H17NO2
- Molgewicht:
- 207.27
- MOL-Datei:
- 29342-05-0.mol
|
Ciclopirox Eigenschaften
- Schmelzpunkt:
- 1440C
- Siedepunkt:
- 350.0±25.0 °C(Predicted)
- Dichte
- 1.193±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Slightly soluble in water, freely soluble in anhydrous ethanol and in methylene chloride
- Aggregatzustand
- Solid
- pka
- 6.25±0.58(Predicted)
- Farbe
- Off-White
- CAS Datenbank
- 29342-05-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
UN 3077 9 / PGIII |
|
|
| HS Code |
2933790002 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
Ciclopirox Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or Light-Yellow Powder
Verwenden
Ciclopirox (Penlac) is a synthetic antifungal agent. Ciclopirox (Penlac) is used for topical dermatologic treatment of superficial mycoses. Ciclopirox (Penlac) is most useful against Tinea versicolor. [1] In a study conducted to further elucidate ciclopir
Definition
ChEBI: A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, repectively. A broad spectrum antigfungal agent, it also exhibits antibacterial acti
ity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.
Mechanism of action
Ciclopirox has a unique mechanism of action through chelation of polyvalent cations, such as Fe3+, which causes inhibition of a number of metal-dependent enzymes within the fungal cell.
Mechanism of action
Ciclopirox is a substituted pyridione derivative. Experiments show that the mechanism of action involves a disruption of transport mechanisms into the cell plasma, especially the uptake of leucine. Further, the uptake of other amino acids such as phenylalanine and lysine, as well as the uptake of potassium and phosphate ions is impaired. This all probably involves a change in membrane permeability, as reported for some other antimycotics, although ciclopirox does not show lytic activity. Consecutively, the substance significantly reduces fungal growth rates.
Clinical Use
Ciclopirox is a hydroxylated pyridinone that is employed for superficial dermatophytic infections, principally onychomycosis.
Ciclopirox Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ciclopirox Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 338)Lieferanten
29342-05-0(Ciclopirox)Verwandte Suche:
- 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE
- CICLOPIROX
- CIELOPIROX
- Brumixol
- Ciciopirox
- Cidochem
- Dafnegin
- geprox
- gopmx
- Micoxolamina
- Mycoster
- 6-Cyclohexyl-1-hydroxy-4-methyl-2[1H]-pyridinone
- 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
- 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-
- 2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-
- 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2-one
- Loprox
- Ciclopirox (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone)
- 6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone
- Ciclopirox (50 mg)
- Ciclopirox (Penlac)
- HOE296b
- 6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone
- Ciclopirox CRS
- Ciclopirox USP/EP/BP
- Ciclopirox (HOE 296)
- CiclopiroxQ: What is
Ciclopirox Q: What is the CAS Number of
Ciclopirox Q: What is the storage condition of
Ciclopirox Q: What are the applications of
Ciclopirox
- Ciclopirox (1134018)
- Penlac
- 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one
- Ring pyrazole ketones
- 13C6]-Ciclopirox
- Isepamicin Impurity 5
- Cyclopyrrolidone amine
- 29342-05-0
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- Batrafen, Loprox, Mycoster, Stieprox, HOE 296b
- Heterocycles
