98717-15-8
98717-15-8 結(jié)構(gòu)式
基本信息
N-(2,6-二甲基苯基)-1-正丙基哌啶-2-甲酰胺鹽酸鹽
鹽酸羅哌卡因
S—鹽酸羅哌卡因
羅哌卡因(鹽酸或甲磺鹽)
甲磺酸羅哌卡因
鹽酸羅派卡因
鹽酸羅哌卡因
ROPIVACAINE HCL
ROPIVACAINE HYDROCHLORIDE
ROPIVCACAINE HYDROCHLORIDE
(s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
S-ROPIVACAINE HCL
(S)-ROPIVACAINE HYDROCHLORIDE
Ropivacaine mesilate
Ropivacaine hydrochloride
物理化學(xué)性質(zhì)
常見問題列表
高濃度時(shí), 布吡卡因?qū)類和C類神經(jīng)纖維的復(fù)合動(dòng)作電位的抑制作用分別比鹽酸羅派卡因強(qiáng)16%和3%,表明鹽酸羅派卡因和布吡卡因的感覺阻滯作用類似,但鹽酸羅派卡因的運(yùn)動(dòng)阻滯作用弱。低濃度時(shí), 鹽酸羅派卡因主要阻滯感覺神經(jīng)纖維,對運(yùn)動(dòng)神經(jīng)纖維的阻滯輕,即鹽酸羅派卡因具有高度的感覺與運(yùn)動(dòng)神經(jīng)阻滯分離的特性,對術(shù)后硬膜外鎮(zhèn)痛有獨(dú)特的優(yōu)點(diǎn)。
IC50: sodium ion influxIC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)
Epidural administration of Ropivacaine hydrochloride effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.
Ropivacaine hydrochloride inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).
Ropivacaine hydrochloride prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.
Ropivacaine hydrochloride inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs.
| Animal Model: | Adult Sprague-Dawley rats (300–400g) |
| Dosage: | 1 μM |
| Administration: | Infusion (added to the perfusate reservoir) |
| Result: | Attenuated pressure-dependent increases in filtration coefficient (K f ). |