302-95-4
302-95-4 結構式
基本信息
去氧膽酸鈉
3A,12A-DIHYDROXYCHOLANIC ACID SODIUM SALT
3ALPHA,12ALPHA-DIHYDROXY-5-BETA-CHOLAN-24-OIC ACID, SODIUM SALT
3ALPHA,12ALPHA-DIHYDROXY-5BETA-CHOLANIC ACID SODIUM SALT
5-BETA-CHOLAN-24-OIC ACID-3A,12A-DIOLE SODIUM SALT
5BETA-CHOLANIC ACID-3ALPHA,12ALPHA-DIOL SODIUM
5-BETA-CHOLANIC ACID-3-ALPHA, 12-ALPHA-DIOL SODIUM SALT
7-DEOXYCHOLIC ACID SODIUM SALT
CHOLEIC ACID SODIUM SALT
DEOXYCHOLIC ACID NA-SALT
DEOXYCHOLIC ACID SODIUM SALT
DESOXYCHOLIC ACID SODIUM SALT
OXIDE EXTRACT
SODIUM CHOLEATE
SODIUM DEOXYCHOLATE
SODIUM DESOXYCHOLATE
(3-alpha,5-beta,12-alpha)-12-dihydroxy-cholan-24-oicacidmonosodiumsalt
3,12-dihydroxy-,monosodiumsalt,(3.alpha.,5.beta.,12.alpha.)-Cholan-24-oicacid
3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-oicacisodiumsalt
cholan-24-oicacid,3,12-dihydroxy-,monosodiumsalt,(3-alpha,5-beta,12-alph
物理化學性質
常見問題列表
以9α-羥基雄-4-烯-3,17-二酮（化合物25）為起始原料，氫化、提純后,得化合物26，惰性氣氛下向化合物26的DCM溶液中添加硫酸，攪拌，反應完全后洗滌、真空蒸餾，得灰白色固體化合物27，在-40℃至-45℃惰性氣氛下，向化合物27的THF溶液中加入三叔丁基氧氫化鋁鋰，攪拌反應完全后，添加HCl溶液淬滅反應混合物，分離各相并萃取水層，洗滌、蒸發(fā)，得化合物28。向溴化乙基三苯基膦的THF溶液中逐滴添加叔丁醇鉀，攪拌1h后向體系中加入化合物28，使反應完全，冰水淬滅，MTBE萃取水層，洗滌并合并有機萃取物，真空濃縮有機層，MTBE純化粗物質，過濾，蒸餾，制備出化合物29，加入三乙胺、DMAP和乙酸酐，反應得化合物30，經(jīng)由化合物84或85轉化為化合物32，向化合物32的乙酸乙酯溶液中添加TBHP水溶液，0℃下緩慢添加次氯酸鈉，攪拌反應，分離并萃取，合并有機層，亞硫酸鈉溶液處理2h后用氯鉻酸吡啶鎓處理有機層，洗滌并蒸發(fā)有機層，純化得淺黃色固體狀化合物24，用Pd/C氫化還原環(huán)上的雙鍵，并用三叔丁氧基氫化鋁鋰還原羰基得到化合物34，堿性條件下水解得脫氧膽酸粗品，純化即制得脫氧膽酸，NaOH堿化制得脫氧膽酸鈉。其合成路線如下圖所示。
| Target | Value |
|
GPCR19
() |
Deoxycholic acid (DCA) and chenoDeoxycholic acid (CDCA), as the common ingredients of duodenal reflux, act synergistically in many physiological and pathological processes. The cells are repeatedly exposed to 100 μM CDCA and Deoxycholic acid at pH 5.5 for up to 120 min. To simulate chronic local recurrent disease in vitro, the gastric cancer cell line MGC803 is exposed to acidified medium (pH 5.5) containing 100 μM Deoxycholic acid and CDCA. An untreated log-growth MGC803 cell line is generated to be used as a control in normal pH media. After daily 10 min exposure to the acidified bile acids for 60 weeks, MGC803-resistant cells are able to survive and proliferate after 120 min exposure.
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/11 | XW30295405 | 脫氧膽酸鈉 | 302-95-4 | 5G | 109元 |
| 2024/11/11 | XW03029544 | 脫氧膽酸鈉 sodium deoxycholate;3α,12α-dihydroxy-5β-cholanic acid sodium salt;7-deoxycholic acid sodium salt;desoxycholic acid sodium salt | 302-95-4 | 25G | 230元 |
| 2024/11/08 | 21859 | 脫氧膽酸鈉 Deoxycholic acid, sodium salt, 99%, extra pure, Thermo Scientific Chemicals | 302-95-4 | 25g | 591元 |