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168835-82-3

中文名稱 (E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺
英文名稱 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
CAS 168835-82-3
分子式 C25H30N2O2
分子量 390.518
MOL 文件 168835-82-3.mol
更新日期 2024/10/25 11:12:37
168835-82-3 結(jié)構(gòu)式 168835-82-3 結(jié)構(gòu)式

基本信息

中文別名
化合物SU1498
(E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺
(E)-2-氰基-3-(4-羥基-3,5-二異丙基苯基)-N-(3-苯基丙基)丙烯酰胺
英文別名
CS-1481
CHEMBL261508
SU1498, >98%
Tyrphostin SU 1498, >98%
(E)-2-CYANO-3-(4-HYDROXY-3
AG-1498
TYRPHOSTIN SU 1498
5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-

物理化學(xué)性質(zhì)

熔點(diǎn)126 °C
沸點(diǎn)590.6±50.0 °C(Predicted)
密度1.100±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度溶于二甲基亞砜。
酸度系數(shù)(pKa)10.30±0.36(Predicted)
形態(tài)粉末
顏色白色至米色
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20° 下保存長達(dá) 3 個(gè)月。
CAS 數(shù)據(jù)庫168835-82-3

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
海關(guān)編碼2926.90.4801
(E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19U0103SU 1498
SU 1498
168835-82-35mg220元
2024/08/19U0103SU 1498
SU 1498
168835-82-325mg1030元
2024/08/19S6535(E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺
SU1498
168835-82-35mg794.93元

常見問題列表

生物活性
SU1498是KDR抑制劑,IC50為0.7 μM,可在內(nèi)皮細(xì)胞中刺激磷酸化ERK1/2的累積。
靶點(diǎn)
TargetValue
KDR
()
體外研究

SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.

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