168835-82-3
168835-82-3 結(jié)構(gòu)式
基本信息
(E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺
(E)-2-氰基-3-(4-羥基-3,5-二異丙基苯基)-N-(3-苯基丙基)丙烯酰胺
CHEMBL261508
SU1498, >98%
Tyrphostin SU 1498, >98%
(E)-2-CYANO-3-(4-HYDROXY-3
AG-1498
TYRPHOSTIN SU 1498
5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | U0103 | SU 1498 SU 1498 | 168835-82-3 | 5mg | 220元 |
| 2024/08/19 | U0103 | SU 1498 SU 1498 | 168835-82-3 | 25mg | 1030元 |
| 2024/08/19 | S6535 | (E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺 SU1498 | 168835-82-3 | 5mg | 794.93元 |
常見問題列表
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KDR
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SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.