14984-68-0
基本信息
鹽酸氯哌丁
鹽酸氯哌斯汀
4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE
CHLOPERASTINE HYDROCHLORIDE
CLOPERASTINE HCL
CLOPERASTINE HYDROCHLORIDE
1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)piperidinehydrochloride
1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride
1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato
2-piperidinoethylp-chlorobenzhydryletherhydrochloride
cloperastinacloridrato
ht11
hustazol
4-chlorobenzhydryl 2-(1-piperidyl)ethyl ether
物理化學性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | C3038 | 氯哌斯汀鹽酸鹽 Cloperastine Hydrochloride | 14984-68-0 | 5g | 290元 |
2024/11/08 | HY-B2133 | 鹽酸氯哌斯丁 Cloperastine hydrochloride | 14984-68-0 | 500mg | 300元 |
2024/11/08 | HY-B2133 | 鹽酸氯哌斯丁 Cloperastine hydrochloride | 14984-68-0 | 10mM * 1mLin DMSO | 330元 |
常見問題列表
27 nM (K + currents)
Cloperastine inhibits the hERG K
+
currents in a concentrationdependent manner with an IC
50
value of 27 nM.
Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic
action potential (MAP) duration without affecting PR interval or QRS width.
Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD
50
in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.