| Identification | More | [Name]
Levosulpiride | [CAS]
23672-07-3 | [Synonyms]
(-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXY-BENZAMIDE
LEVOSULPIRIDE
(-)-N-1-[ETHYLPYRROLIDIN-2-YLMETHYL]-2-METHOXY-5-SULFAMOYLBENZAMIDE
(S)-(-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE
(S)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE
(S)-(-)-SULPIRIDE
(-)-SULPIRIDE
(s)-(-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
(s)-(-)-o-anisamid
5-(aminosulfonyl)-n-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-benzamid(
levopraid
rv-12309
s-(-)-n-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylebenzamide
Levosulpride
(S)-(-)-Sulpiride, Vetranal
S(-)-SULPIRIDE DOPAMINE D1 ANTAGONIS
LEVOSULPIRIDE/LEVOSULPRIDE
Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-, (S)-
Benzamide, 5-(aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy-(9CI)
l-Sulpiride | [EINECS(EC#)]
233-599-4 | [Molecular Formula]
C15H23N3O4S | [MDL Number]
MFCD00055220 | [Molecular Weight]
341.43 | [MOL File]
23672-07-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
183-186 °C(lit.) | [density ]
1.236±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMF (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
9.98±0.60(Predicted) | [color ]
White to Off-White | [Merck ]
13,9080 | [InChIKey]
BGRJTUBHPOOWDU-NSHDSACASA-N | [CAS DataBase Reference]
23672-07-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [RIDADR ]
3077 | [WGK Germany ]
3
| [RTECS ]
BZ3400100
| [HS Code ]
29350090 | [Toxicity]
LD50 oral in rabbit: > 1500mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
dopamine receptor antagonists | [Uses]
(S)-(?)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels10 and on depression-like behavior in ovariectomized female rats.11 | [Uses]
Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic. | [Definition]
ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4,
1 and D5 receptors respectively). | [General Description]
(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders. | [Biological Activity]
Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). | [Biochem/physiol Actions]
(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9 | [storage]
Room temperature |
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