ChemicalBook CAS DataBase List exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol

exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol synthesis

11synthesis methods

Product Name:exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol
CAS Number:419572-18-2
Molecular formula:C11H19NO3
Molecular Weight:213.27

24424-99-5 Synthesis

24424-99-5
840 suppliers
$13.50/25G

(1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol

134575-13-6
89 suppliers
$60.00/100mg

exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol

419572-18-2
78 suppliers
$52.00/100mg

Yield: 89.9%

Reaction Conditions:

with sodium hydroxide in 1,4-dioxane;water at 20 - 30; for 10 h;

Steps:

31.1 Example 31 Step 1 (1R,5S,6R)-tert-Butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
(1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-ylmethanol 31a (10 g, 88.4 mmol) was dissolved in a mixed solvent of dioxane and H₂O (V/V=3/2), followed by addition of sodium hydroxide (4.2 g, 106 mmol) and di-tert-butyl dicarbonate (28.9 g, 132.6 mmol).
After reacting for 10 hours, 50 mL of H₂O was added to the reaction mixture.
The reaction mixture was extracted with ethyl acetate (150 mLx3).
The organic phases were combined, washed with saturated sodium chloride solution (50 mLx2), dried over anhydrous sodium sulfate, and filtered.
The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with elution system C to obtain the title product (1R,5S,6R)-tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 31b (16.9 g, yield 89.9%) as a light yellow liquid.

References:

Location in patent:Paragraph 0306; 0307

134575-37-4 Synthesis