Di-tert-butyl dicarbonate suppliers
Di-tert-butyl dicarbonate
- CAS:
- 24424-99-5
- MF:
- C10H18O5
- MW:
- 218.25
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Properties
- Melting point:
- 23 °C (lit.)
- Boiling point:
- 56-57 °C/0.5 mmHg (lit.)
- Density
- 0.95 g/mL at 25 °C (lit.)
- vapor pressure
- 3.85Pa at 25℃
- refractive index
- n
20/D 1.409(lit.)
- Flash point:
- 99 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Low Melting Crystalline Solid
- color
- White
- Specific Gravity
- 0.950
- Water Solubility
- Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
- Sensitive
- Moisture Sensitive
- BRN
- 1911173
- Stability:
- Acid Sensitive
- InChIKey
- DYHSDKLCOJIUFX-UHFFFAOYSA-N
- LogP
- 1.87 at 25℃
- CAS DataBase Reference
- 24424-99-5(CAS DataBase Reference)
- EPA Substance Registry System
- Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)
Safety Information
- Symbol(GHS)
GHS02,GHS05,GHS06
- Signal word
- Danger
- Hazard statements
- H226-H315-H317-H318-H330-H335
- Precautionary statements
- P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
- Hazard Codes
- T+,T,F,Xi,F+
- Risk Statements
- 11-19-26-36/37/38-43-10-40
- Safety Statements
- 16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
- RIDADR
- UN 2929 6.1/PG 1
- WGK Germany
- 3
- RTECS
- HT0230000
- Autoignition Temperature
- 460 °C
- Hazard Note
- Flammable/Irritant/Very Toxic
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- I
- HS Code
- 29209010
- Toxicity
- LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Use
Di-tert-butyl dicarbonate (Boc2O) and di-tert-butyl tricarbonate ((BocO)2CO) have been used as amine carbonylating reagents to obtain linear or branched aliphatic isocyanates. most of the known methods for transforming amines into isocyanates are not mild enough and furnish undefined products as a result of uncontrolled side reactions. However, 4-dimethylaminopyridine (DMAP)-catalyzed reaction with activated carbonates as C1 building blocks constitutes a convenient laboratory method for the phosgene-free isocyanation of amines. A procedure has been described whereby alkyl- and arylamines are converted into isocyanates in high yields by reaction with activated carbonates (for example, di-tert-butyl dicarbonate, Boc2O) in the presence of a catalytic amount of a nucleophilic nitrogen base at room temperature. Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. The reaction of substituted anilines with Boc2O in the presence of a stoichiometric amount of 4-dimethylaminopyridine (DMAP) in an inert solvent (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) at room temperature leads to aryl isocyanates in almost quantitative yields within 10 min.
697 supplier list of "Di-tert-butyl dicarbonate"
- Product Name:Di-tert-butyl dicarbonate
- Company Type: Trader
- Country/Region: CHINA
- Product Name:di-tert-butyl dicarbonate
- Products Intro:Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Octane booster,lubricant additve,specialty chemicals,ingredients
- Product Name:Di-tert-butyl dicarbonate
- Products Intro:Purity: 0.99 | Package: 1KG;5KG;100KG;1000KG | CustNote: 1KG,5KG,25KG,200KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Tert-butoxycarbonyl anhydride
- Products Intro:Package: 5KG;70KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: N,N-Diethyl-3-methylbenzamide,β-Nicotinamide Mononucleotide NMN,2-Ethylhexanoic Acid,Sodium Cocoyl Isethionate,Glutathione powder Whitening
- Product Name:Di-tert-butyl Dicarbonate (Di-Boc)
- Products Intro:Purity: 99% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Peptide Chemical,Heterocyclic compound,Organoboron Compound,Linker
- Product Name:Di- tert-butyl dicarbonate (DIBOC)
- Products Intro:Package: 50kg;170kg
- Company Type: Manufacturer
- Country/Region: CHINA
- Product Name:Di-tert-butyl dicarbonate
- Products Intro:Purity: 99% | Package: 5KG;25KG | CustNote: High quality
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pregabalin,1-Phenyl-2-nitropropene,4-Chlorobenzophenone,N-(tert-Butoxycarbonyl)-4-piperidone,tert-Butyl 4-anilinopiperidine-1-carboxylate
$20.00-15.00 / 1kg
- Product Name:Di-tert-butyl dicarbonate
- Products Intro:Purity: 99%|Package: 1kg;20.00;USD|10000kg;18.00;USD|2e+007kg;15.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1-Octadecanol,AMP 95,Polyisobutylene,tetramisole hcl,Ivermectin
- Product Name:Di-tert-Butyldicarbonate
- Products Intro:Purity: .99
- Company Type: Trader
- Country/Region: CHINA
- Main Products: DIETHYL ALLYLPHOSPHONATE,pentaerythritol triallyl ether,DIBENZYLAMINE
$0.00/ 1kg
- Product Name:Di-Tert-Butyl Dicarbonate
- Products Intro:Purity: 99%|Package: 1kg;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 28578-16-7,5449-12-7,148553-50-8,49851-31-2,71368-80-4