Dimethyl Furan-2,5-dicarboxylate synthesis

13synthesis methods

Product Name:Dimethyl Furan-2,5-dicarboxylate
CAS Number:4282-32-0
Molecular formula:C8H8O5
Molecular Weight:184.15

Dimethyl Furan-2,5-dicarboxylate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process. It can be synthesized by the condensation of 2,5-furandicarboxylic acid and dimethyl carbonate.

3238-40-2 Synthesis

3238-40-2
455 suppliers
$6.00/1g

616-38-6 Synthesis

616-38-6
674 suppliers
$5.00/5 g

4282-32-0
217 suppliers
$16.96/1gm:

Yield:4282-32-0 98.62%

Reaction Conditions:

with tetramethylammonium bromide;lithium carbonate in N,N-dimethyl-formamide at 150; for 10.5 h;Temperature;Reagent/catalyst;Solvent;

Steps:

1-41
In a 500ml three-necked flask, add 15ml of N,N-dimethylformamide as solvent, and then add 465mg (3mmol) of 2,5-furandicarboxylic acid, 1.35g (15mmol) of dimethyl carbonate, 0.3mmol Lithium carbonate and 1mmol of tetramethylammonium bromide form a heterogeneous reaction system. The temperature is raised to 150°C in an oil bath, and the temperature rise time is controlled within 0.5h. The reaction is carried out for 10h under magnetic stirring (600r/min). After the reaction, it was allowed to stand, and the supernatant was taken for liquid chromatography analysis to determine the yield of dimethyl 2,5-furandicarboxylate. The test conditions of high performance liquid chromatography are: Agilent 1200, Agilent ZORBAX Eclipse XDB C18 Column, mobile phase is CH3OH:H2O=50:50, flow rate is 1.0ml/min, column temperature is 30, detection wavelength is 270nm,Calculated by high performance liquid chromatography, the yield of dimethyl 2,5-furandicarboxylate was 98.62%.

References:

Tianjin Polytechnic University;Su Kunmei;Meng Chunyu;Li Zhenhuan CN112079801, 2020, A Location in patent:Paragraph 0025-0028; 0030-0031; 0032-0033; 0034-0144

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