3,5-Dimethyl-4-methoxy-2-pyridinemethanol synthesis
- Product Name:3,5-Dimethyl-4-methoxy-2-pyridinemethanol
- CAS Number:86604-78-6
- Molecular formula:C9H13NO2
- Molecular Weight:167.21
86604-75-3
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86604-78-6
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$7.00/5g
Yield:86604-78-6 83%
Reaction Conditions:
with potassium iodide;sodium hydroxide in methanol;water for 4 h;Reflux;Reagent/catalyst;
Steps:
1.b b. Preparation of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine (V)
Take 80 g of 2- (chloromethyl) -4-methoxy-3,5-dimethylpyridine hydrochloride,Add 300 mL of methanol,150 mL water,5.4 g Potassium iodide,40.4 g sodium hydroxide,Stirring heated to reflux, the reaction 4 h.Remove the methanol by rotary evaporation, add 300 mL of drinking water and extract with methylene chloride (150 mL × 3). Combine the organic phases. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, concentrated,50.0 g red oily liquid. Yield 83.0%
References:
Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Pan Zhaoxi;Zhang Da;Gao Yongchen;Zhang Mingming CN107382963, 2017, A Location in patent:Paragraph 0013; 0017; 0021
91219-90-8
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86604-78-6
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150054-50-5
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$54.00/100mg
86604-78-6
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86604-80-0
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86604-78-6
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187222-18-0
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86604-78-6
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