ChemicalBook CAS DataBase List Methyl 4-Methoxy-3,5-diMethylpicolinate

Methyl 4-Methoxy-3,5-diMethylpicolinate synthesis

7synthesis methods

Product Name:Methyl 4-Methoxy-3,5-diMethylpicolinate
CAS Number:187222-18-0
Molecular formula:C10H13NO3
Molecular Weight:195.22

447461-21-4 Synthesis

2-Pyridinecarboxylicacid,4-hydroxy-3,5-dimethyl-(9CI)

447461-21-4
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187222-18-0
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Yield:187222-18-0 65%

Reaction Conditions:

in N-methyl-acetamide;water;

Steps:

10 Synthesis of 4-Methoxy-2-methoxycarbonyl-3,5-Lutidine from 2-carboxy-4-hydroxy-3,5-lutidine

EXAMPLE 10 Synthesis of 4-Methoxy-2-methoxycarbonyl-3,5-Lutidine from 2-carboxy-4-hydroxy-3,5-lutidine Sodium hydride (60%, 2 eq.) was dissolved in dry dimethylformamide (5 volumes) and 2-carboxy-4-hydroxy-3,5-lutidine (1 eq.) was added. The mixture was stirred under a stream of nitrogen for 15 minutes and lodomethane (2.5 eq.) was added. The mixture was stirred at room temperature for 12 hours. Deionized water was added and the product was extracted three times with dichloromethane. The combined organic extracts were dried over sodium sulfate, filtered and the solvent was evaporated to give the 4-Methoxy-2-methoxycarbonyl-3,5-Lutidine product as a light brown oil in 65% yield.

References:

US6437139,2002,B1

67-56-1 Synthesis