2,3,5-Trimethylpyridine-1-Oxide synthesis
- Product Name:2,3,5-Trimethylpyridine-1-Oxide
- CAS Number:74409-42-0
- Molecular formula:C8H11NO
- Molecular Weight:137.18
695-98-7
313 suppliers
$6.00/5g
74409-42-0
107 suppliers
$80.00/250mg
Yield: 91%
Reaction Conditions:
with dihydrogen peroxide;methyltrioxorhenium(VII) in dichloromethane;water at 20; for 3 h;
Steps:
1
Example 1: Oxidation of the pyridines To a solution of 2,3, 5-colidine (1) (2 g, 0. 016 mol) in dichloromethane (10 ml) was added hydrogen peroxide 30% (5 eq. ) and methyltrioxorhenium (MTO) (1.5% mol). After 3 hours in stirring at room temperature, it was added a aqueous solution of NaHS03 (10 ml). The two phases were separated and the aqueous phase was extracted with dichloromethane (3x50 ml). The organic phases were dried with anhydrous sodium sulfate and the solvent was evaporated, yielding a solid (= 91%).
References:
HERBEX, PRODUTOS QUíMICOS, SA;SARAGGA, José, Manuel WO2003/97606, 2003, A1 Location in patent:Page/Page column 11
695-98-7
313 suppliers
$6.00/5g
75-09-2
1209 suppliers
$10.00/25 mL
7722-84-1
5 suppliers
$23.30/*2x50ml
74409-42-0
107 suppliers
$80.00/250mg