ChemicalBook CAS DataBase List 2,3,5-Collidine

2,3,5-Collidine synthesis

7synthesis methods

Product Name:2,3,5-Collidine
CAS Number:695-98-7
Molecular formula:C8H11N
Molecular Weight:121.18

591-22-0
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$11.19/25ML

71-23-8 Synthesis

71-23-8
760 suppliers
$12.00/100g

695-98-7
311 suppliers
$6.00/5g

Yield:695-98-7 90%

Reaction Conditions:

with Raneynickel at 180; for 0.5 h;Flow reactor;Green chemistry;regioselective reaction;Concentration;

Steps:

3.2. General Flow Procedure for the Synthesis of 2-Methylpyridines
General procedure: The continuous flow system was set up as described in Figure 1 by using either a Waters 515 pump or Vapourtec R2 pumping module to progress 1-propanol through a stainless steel column (150 × 4.6 mm) packed with 5.5 g of Raney nickel. Initially, while a 0.05 M solution of the respective pyridine was prepared in 5 mL of 1-propanol, the flow rate was set to 0.3 mL/min and the catalyst column was heated in a sand bath to >180 °C for 30 min. The flow rate was then set to 0.1 mL/min and the sample was placed in a 5 mL sample loop and introduced into the reaction stream. The dead volume had been estimated at ~1 mL (~2.5 mL max theoretical, 150 × 4.6mm cylinder) giving a ~10 min residence time: however, the sample was collected for 30 min to ensure complete collection. The solvent was evaporated to yield a product that was of sufficient purity for further use.

References:

Manansala, Camille;Tranmer, Geoffrey K. [Molecules,2015,vol. 20,# 9,p. 15797 - 15806]

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