ChemicalBook CAS DataBase List 3-Aminoacetophenone

3-Aminoacetophenone synthesis

9synthesis methods

Product Name:3-Aminoacetophenone
CAS Number:99-03-6
Molecular formula:C8H9NO
Molecular Weight:135.16

121-89-1
413 suppliers
$5.00/10g

99-03-6
403 suppliers
$6.00/10g

Yield:99-03-6 100%

Reaction Conditions:

with water;oxalic acid;titanium(IV) oxide for 3 h;Irradiation;Inert atmosphere;Sealed tube;Green chemistry;chemoselective reaction;Wavelength;

Steps:

General procedure: Nitro compounds (0.1 mmol under sunlight and 0.5 mmol under UV LED irradiation) were dissolved in PEG-400 (1.5 ml) and then 10 ml of water was added to the solution; commercial TiO2 (P25) (40 mg) and oxalic acid (1.5 equimolar) were added into a round bottom Pyrex flask (25 ml). The reaction mixture was degassed by Argon gas (20 min) and sealed with a septum. Afterwards, the flask was irradiated under stirring with sunlight or violet LED (see the data in Table 2). After the completion of the reaction according to GC monitoring, NaHCO3 was added to increase pH = 7 and the mixture was stirred at room temperature. The aqueous layer was extracted with EtOAc (2x10 ml). The organic layer was dried with sodium sulfate, filtered and evaporated in vacuum.

References:

Ramdar, Moosa;Kazemi, Foad;Kaboudin, Babak [Chemical Papers,2017,vol. 71,# 6,p. 1155 - 1163]

FullText

54060-30-9 Synthesis