TPCA-1
|
- $59 - $1802
- Product name: TPCA-1
- CAS: 507475-17-4
- MF: C12H10FN3O2S
- MW: 279.29
- EINECS:
- MDL Number:MFCD09037541
- Synonyms:TPCA-1;2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide;TPCA-1(TPCA 1);3-ThiophenecarboxaMide, 2-[(aMinocarbonyl)aMino]-5-(4-fluorophenyl)-;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide TPCA-1;TPCA-1 IKK-2 Inhibitor IV;GW683965
37 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 500μg
- 1MG
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 500mg
- 10
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product numberX5305
- Product descriptionTPCA-1
- Packaging10mg
- Price$347
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging5mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging50mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging100mg
- Price$443
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging250mg
- Price$666
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA377370
- Product descriptionTPCA-1 98+%
- Packaging1g
- Price$1665
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008300
- Product descriptionTPCA-1 95.00%
- Packaging1MG
- Price$200.55
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008300
- Product descriptionTPCA-1 95.00%
- Packaging10MG
- Price$750.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4602
- Product descriptionTPCA-1
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60174
- Product descriptionTPCA-1
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181024
- Product descriptionTPCA-1 >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181024
- Product descriptionTPCA-1 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181024
- Product descriptionTPCA-1 >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT100211
- Product descriptionTPCA-1
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT100211
- Product descriptionTPCA-1
- Packaging100mg
- Price$200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5305 | TPCA-1 | 10mg | $347 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 5mg | $59 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 10mg | $110 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 50mg | $222 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 100mg | $443 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 250mg | $666 | 2021-12-16 | Buy |
| Ambeed | A377370 | TPCA-1 98+% | 1g | $1665 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008300 | TPCA-1 95.00% | 1MG | $200.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008300 | TPCA-1 95.00% | 10MG | $750.7 | 2021-12-16 | Buy |
| ApexBio Technology | A4602 | TPCA-1 | 10mg | $120 | 2021-12-16 | Buy |
| Arctom | CFN60174 | TPCA-1 | 10mg | $288 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181024 | TPCA-1 >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181024 | TPCA-1 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181024 | TPCA-1 >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT100211 | TPCA-1 | 50mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT100211 | TPCA-1 | 100mg | $200 | 2021-12-16 | Buy |
Properties
Melting point :>217°C (dec.)
Boiling point :442.6±45.0 °C(Predicted)
Density :1.490
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :13.12±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :442.6±45.0 °C(Predicted)
Density :1.490
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :13.12±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively. At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.Related product price
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