PLX5622
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- $26 - $1800
- Product name: PLX5622
- CAS: 1303420-67-8
- MF: C21H19F2N5O
- MW: 395.41
- EINECS:
- MDL Number:MFCD32201039
- Synonyms:PLX5622;PLX 5622;PLX-5622;3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-;5-Fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine;PLX5622 USP/EP/BP;6-FLUORO-N-((5-FLUORO-2-METHOXYPYRIDIN-3-YL)METHYL)-5-((5-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)METHYL)PYRIDIN-2-AMINE;PLX5622,PLX 5622,Inhibitor,CSF-1 receptor,microglial,CSF1R,orally,pathology,inhibit,c-Fms,penetrant,preceding,brain,colony stimulating factor 1 receptor,CSF-1R,elimination;6-Fluoro-N-[(5-fluoro-2-methoxy-3-pyridyl)methyl]-5-[(5-methyl-7-azaindole-3-yl)methyl]pyridin-2-amine
13 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number1283DJ
- Product descriptionCID52936034
- Packaging25mg
- Price$935
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28927
- Product descriptionPLX5622
- Packaging25mg
- Price$275
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28927
- Product descriptionPLX5622
- Packaging10mg
- Price$172
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28927
- Product descriptionPLX5622
- Packaging5mg
- Price$106
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28927
- Product descriptionPLX5622
- Packaging1mg
- Price$26
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0077157
- Product descriptionPLX5622 99.86%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077157
- Product descriptionPLX5622 99.86%
- Packaging10mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077157
- Product descriptionPLX5622 99.86%
- Packaging25mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077157
- Product descriptionPLX5622 99.86%
- Packaging50mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077157
- Product descriptionPLX5622 99.86%
- Packaging100mg
- Price$950
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21518
- Product descriptionPLX5622 >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21518
- Product descriptionPLX5622 >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21518
- Product descriptionPLX5622 >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1283DJ | CID52936034 | 25mg | $935 | 2021-12-16 | Buy |
| Cayman Chemical | 28927 | PLX5622 | 25mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 28927 | PLX5622 | 10mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 28927 | PLX5622 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 28927 | PLX5622 | 1mg | $26 | 2024-03-01 | Buy |
| ChemScene | CS-0077157 | PLX5622 99.86% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0077157 | PLX5622 99.86% | 10mg | $195 | 2021-12-16 | Buy |
| ChemScene | CS-0077157 | PLX5622 99.86% | 25mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-0077157 | PLX5622 99.86% | 50mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-0077157 | PLX5622 99.86% | 100mg | $950 | 2021-12-16 | Buy |
| DC Chemicals | DC21518 | PLX5622 >98% | 100mg | $450 | 2021-12-16 | Buy |
| DC Chemicals | DC21518 | PLX5622 >98% | 250mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC21518 | PLX5622 >98% | 1g | $1800 | 2021-12-16 | Buy |
Properties
Density :1.364±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13?+-.0.40(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13?+-.0.40(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
PLX5622 (1303420-67-8) is a highly selective (>20 fold over KIT and FLT3, >60 fold over 200 other kinases) and brain-penetrant inhibitor of colony-stimulating factor 1 receptor (CSF1R; IC50 = 16 nM).1 It prevented plaque formation in 5xFAD1 and 3xTg2 mouse models of Alzheimer’s disease via elimination of microglia in a CSF1R-dependent manner.? PLX5622 showed efficacy in a mouse neuropathic pain model via reduction of CD86+ macrophages resulting in reduced expression of pro-inflammatory cytokines.3 It also was able to ameliorate peripheral neuropathy in aging mice.4 PLX5622 displayed neuroprotective effects during the chronic phase of a traumatic brain injury mouse model.5? PLX5622 has also been shown to affect myeloid and lymphoid compartments, indicating that its affects are not limited to microglia and include peripheral immune cells.6Related product price
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