Dabrafenib
- $9 - $5400
- Product name: Dabrafenib
- CAS: 1195765-45-7
- MF: C23H20F3N5O2S2
- MW: 519.56
- EINECS:689-166-9
- MDL Number:MFCD17215684
- Synonyms:Dabrafenib;Dabrafenib free base(GSK2118436A);GSK2118436A;Dabrafenib (GSK2118436A);Dabrafenib KB-57246;Debrafenib API;BenzenesulfonaMide, N-[3-[5-(2-aMino-4-pyriMidinyl)-2-(1,1-diMethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-;N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
42 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- SynChem
- TRC
Package
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 5g
- 100 mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberJ96885
- Product descriptionDabrafenib
- Packaging500mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1871
- Product descriptionDabrafenib
- Packaging1g
- Price$1001
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging1mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging5mg
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging10mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging50mg
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging100mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging250mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA484347
- Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
- Packaging1g
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1407
- Product descriptionDabrafenib(GSK2118436)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1407
- Product descriptionDabrafenib(GSK2118436)
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1407
- Product descriptionDabrafenib(GSK2118436)
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0192
- Product descriptionDabrafenib
- Packaging1mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0192
- Product descriptionDabrafenib
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0192
- Product descriptionDabrafenib
- Packaging10mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60005
- Product descriptionDabrafenib ≥98%
- Packaging20mg
- Price$168
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | J96885 | Dabrafenib | 500mg | $390 | 2021-12-16 | Buy |
AK Scientific | Y1871 | Dabrafenib | 1g | $1001 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 1mg | $9 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 5mg | $15 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 10mg | $20 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 50mg | $34 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 100mg | $44 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 250mg | $87 | 2021-12-16 | Buy |
Ambeed | A484347 | N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% | 1g | $218 | 2021-12-16 | Buy |
ApexBio Technology | B1407 | Dabrafenib(GSK2118436) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
ApexBio Technology | B1407 | Dabrafenib(GSK2118436) | 10mg | $70 | 2021-12-16 | Buy |
ApexBio Technology | B1407 | Dabrafenib(GSK2118436) | 50mg | $150 | 2021-12-16 | Buy |
Apolloscientific | BISN0192 | Dabrafenib | 1mg | $54 | 2021-12-16 | Buy |
Apolloscientific | BISN0192 | Dabrafenib | 5mg | $82 | 2021-12-16 | Buy |
Apolloscientific | BISN0192 | Dabrafenib | 10mg | $115 | 2021-12-16 | Buy |
Arctom | CFN60005 | Dabrafenib ≥98% | 20mg | $168 | 2021-12-16 | Buy |
Properties
Melting point :214-216oC
Boiling point :653.7±65.0 °C(Predicted)
Density :1.443
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
form :White solid.
pka :6.62±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES :C1(S(NC2=CC=CC(C3=C(C4C=CN=C(N)N=4)SC(C(C)(C)C)=N3)=C2F)(=O)=O)=C(F)C=CC=C1F
Boiling point :653.7±65.0 °C(Predicted)
Density :1.443
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
form :White solid.
pka :6.62±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES :C1(S(NC2=CC=CC(C3=C(C4C=CN=C(N)N=4)SC(C(C)(C)C)=N3)=C2F)(=O)=O)=C(F)C=CC=C1F
Safety Information
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Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively). It has been investigated in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors and is often combined with the MEK inhibitor trametinib to circumvent the development of B-Raf inhibitor resistance.Related product price
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Suppliers and manufacturers
career henan chemical co
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
$1.00 /1KG
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide CAS:1195765-45-7
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide CAS:1195765-45-7