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ChemicalBook >> CAS DataBase List >> PLX3397 (Pexidartinib)

PLX3397 (Pexidartinib)

PLX3397 (Pexidartinib) price.
  • $50 - $6850
  • Product name: PLX3397 (Pexidartinib)
  • CAS: 1029044-16-3
  • MF: C20H15ClF3N5
  • MW: 417.81
  • EINECS:-0
  • MDL Number:MFCD28900745
  • Synonyms:5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl);3-Pyridinemethanamine,N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-;N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine;PLX3397 (Pexidartinib);PLX339;5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine;5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine;CS-1695
29 prices
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Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
  • Usbiological
Package
  • 5mg
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  • 25mg
  • 50mg
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  • 250mg
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  • 1g
  • 2g
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  • ManufacturerAK Scientific
  • Product number2971DC
  • Product descriptionPexidartinib
  • Packaging25mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP76492
  • Product descriptionPexidartinib
  • Packaging25mg
  • Price$87.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP76492
  • Product descriptionPexidartinib
  • Packaging100mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18271
  • Product descriptionPexidartinib ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18271
  • Product descriptionPexidartinib ≥98%
  • Packaging10mg
  • Price$115
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18271
  • Product descriptionPexidartinib ≥98%
  • Packaging25mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18271
  • Product descriptionPexidartinib ≥98%
  • Packaging50mg
  • Price$419
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM149380
  • Product description5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine 95%+
  • Packaging100mg
  • Price$325
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging50mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging100mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging200mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging500mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging1g
  • Price$750
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-4256
  • Product descriptionPexidartinib 99.64%
  • Packaging2g
  • Price$1250
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2971DC Pexidartinib 25mg $168 2021-12-16 Buy
Biosynth Carbosynth FP76492 Pexidartinib 25mg $87.5 2021-12-16 Buy
Biosynth Carbosynth FP76492 Pexidartinib 100mg $190 2021-12-16 Buy
Cayman Chemical 18271 Pexidartinib ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 18271 Pexidartinib ≥98% 10mg $115 2024-03-01 Buy
Cayman Chemical 18271 Pexidartinib ≥98% 25mg $270 2024-03-01 Buy
Cayman Chemical 18271 Pexidartinib ≥98% 50mg $419 2024-03-01 Buy
Chemenu CM149380 5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine 95%+ 100mg $325 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 5mg $50 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 10mg $70 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 50mg $150 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 100mg $190 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 200mg $260 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 500mg $450 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 1g $750 2021-12-16 Buy
ChemScene CS-4256 Pexidartinib 99.64% 2g $1250 2021-12-16 Buy

Properties

Density :1.458±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 10 mg/ml)
pka :12.81±0.40(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference :1029044-16-3

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Colony stimulating factor-1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively). It has been used in combination with paclitaxel to block macrophage recruitment in mammary tumor-bearing mice, thus slowing primary tumor development and metastasis. Pexidartinib has also been used to block microglial stimulation of glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme.

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