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ChemicalBook >> CAS DataBase List >> Nutlin 3a

Nutlin 3a

 Nutlin 3a price.
  • $60 - $10302
  • Product name: Nutlin 3a
  • CAS: 675576-98-4
  • MF: C30H30Cl2N4O4
  • MW: 581.49
  • EINECS:
  • MDL Number:MFCD14636430
  • Synonyms:4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone;Nutlin 3a;Nutlin-3a (chiral);2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3a;Nutlin 3a 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-
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  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Iris Biotech GmbH
  • Sigma-Aldrich
  • Tocris
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  • 25
  • 5
  • 10mM(in 1mL DMSO)
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 1g
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging2mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging5mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging10mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging25mg
  • Price$324
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging50mg
  • Price$606
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging1g
  • Price$10302
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004735
  • Product description4-[[(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE 95.00%
  • Packaging5MG
  • Price$503.17
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging10mM(in 1mL DMSO)
  • Price$185
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging50mg
  • Price$580
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging200mg
  • Price$1980
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60190
  • Product descriptionNutlin-3a
  • Packaging10mg
  • Price$288
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1880
  • Product descriptionNutlin-3a-(-)-Nutlin-3 99%
  • Packaging5mg
  • Price$159.5
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1880
  • Product descriptionNutlin-3a-(-)-Nutlin-3 99%
  • Packaging25mg
  • Price$555.5
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number18585
  • Product description(-)-Nutlin-3 ≥98%
  • Packaging1mg
  • Price$93
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number18585
  • Product description(-)-Nutlin-3 ≥98%
  • Packaging5mg
  • Price$230
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 2mg $60 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 5mg $108 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 10mg $154 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 25mg $324 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 50mg $606 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 1g $10302 2021-12-16 Buy
American Custom Chemicals Corporation INB0004735 4-[[(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE 95.00% 5MG $503.17 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 10mg $120 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 10mM(in 1mL DMSO) $185 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 50mg $580 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 200mg $1980 2021-12-16 Buy
Arctom CFN60190 Nutlin-3a 10mg $288 2021-12-16 Buy
Axon Medchem Axon1880 Nutlin-3a-(-)-Nutlin-3 99% 5mg $159.5 2021-12-16 Buy
Axon Medchem Axon1880 Nutlin-3a-(-)-Nutlin-3 99% 25mg $555.5 2021-12-16 Buy
Cayman Chemical 18585 (-)-Nutlin-3 ≥98% 1mg $93 2024-03-01 Buy
Cayman Chemical 18585 (-)-Nutlin-3 ≥98% 5mg $230 2024-03-01 Buy

Properties

Density :1.36
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear
form :White powder
pka :14.35±0.20(Predicted)
color :white to beige
optical activity :[α]/D -140 to -155° (c=0.5, CDCl3)
InChIKey :BDUHCSBCVGXTJM-WUFINQPMSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The protein p53, often called the ‘guardian of the genome,’ is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. Mdm2, a key negative regulator of p53, which is over-expressed in many human tumors, functions by binding to and targeting p53 for proteasomal degradation. Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction. (?)-Nutlin-3 is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It potently inhibits Mdm2-p53 binding with an IC50 value of 0.09 μM, induces the expression of p53-regulated genes, and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. (?)-Nutlin-3 inhibits the proliferation of exponentially growing human skin and murine fibroblasts with IC50 values of 2.2 and 1.3 μM, respectively, and induces substantial tumor shrinkage in mice expressing LnCaP, 22Rv1 or MHM cancer cell lines when treated orally with a 200 mg/kg dose twice daily for two weeks.

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