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ChemicalBook >> CAS DataBase List >> NUTLIN-3

NUTLIN-3

NUTLIN-3 price.
  • $37 - $2245.7
  • Product name: NUTLIN-3
  • CAS: 548472-68-0
  • MF: C30H30Cl2N4O4
  • MW: 581.49
  • EINECS:200-258-5
  • MDL Number:MFCD07784509
  • Synonyms:(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE;NUTLIN-3;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one;Nutlin-3, >=98%;NUTLIN-3 (Free base)
34 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Iris Biotech GmbH
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 5mg
  • 1MG
  • 10
  • 10MG
  • 2x5mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1959AH
  • Product descriptionNutlin-3
  • Packaging25mg
  • Price$248
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008268
  • Product descriptionNUTLIN-3 95.00%
  • Packaging10MG
  • Price$817.39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008268
  • Product descriptionNUTLIN-3 95.00%
  • Packaging1MG
  • Price$579.69
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6058
  • Product description(±)-Nutlin-3
  • Packaging5mg
  • Price$106
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6058
  • Product description(±)-Nutlin-3
  • Packaging10mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6058
  • Product description(±)-Nutlin-3
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1585
  • Product descriptionNutlin-3 99%
  • Packaging2x5mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545889
  • Product descriptionNutlin-3 >98%
  • Packaging5mg
  • Price$244.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180761
  • Product descriptionNutlin-3 >98%
  • Packaging100mg
  • Price$578
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545889
  • Product descriptionNutlin-3 >98%
  • Packaging25mg
  • Price$720.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180761
  • Product descriptionNutlin-3 >98%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180761
  • Product descriptionNutlin-3 >98%
  • Packaging1g
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFN65107
  • Product descriptionNutlin 3A
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10004372
  • Product description(±)-Nutlin-3 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10004372
  • Product description(±)-Nutlin-3 ≥98%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10004372
  • Product description(±)-Nutlin-3 ≥98%
  • Packaging10mg
  • Price$199
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1959AH Nutlin-3 25mg $248 2021-12-16 Buy
American Custom Chemicals Corporation API0008268 NUTLIN-3 95.00% 10MG $817.39 2021-12-16 Buy
American Custom Chemicals Corporation API0008268 NUTLIN-3 95.00% 1MG $579.69 2021-12-16 Buy
ApexBio Technology B6058 (±)-Nutlin-3 5mg $106 2021-12-16 Buy
ApexBio Technology B6058 (±)-Nutlin-3 10mg $156 2021-12-16 Buy
ApexBio Technology B6058 (±)-Nutlin-3 50mg $540 2021-12-16 Buy
Axon Medchem Axon1585 Nutlin-3 99% 2x5mg $154 2021-12-16 Buy
Biorbyt Ltd orb545889 Nutlin-3 >98% 5mg $244.8 2021-12-16 Buy
Biorbyt Ltd orb180761 Nutlin-3 >98% 100mg $578 2021-12-16 Buy
Biorbyt Ltd orb545889 Nutlin-3 >98% 25mg $720.8 2021-12-16 Buy
Biorbyt Ltd orb180761 Nutlin-3 >98% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb180761 Nutlin-3 >98% 1g $2245.7 2021-12-16 Buy
Biosynth Carbosynth FN65107 Nutlin 3A 10mg $175 2021-12-16 Buy
Cayman Chemical 10004372 (±)-Nutlin-3 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 10004372 (±)-Nutlin-3 ≥98% 5mg $109 2024-03-01 Buy
Cayman Chemical 10004372 (±)-Nutlin-3 ≥98% 10mg $199 2024-03-01 Buy

Properties

Melting point :>132oC (dec.)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :solid
pka :14.35±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :BDUHCSBCVGXTJM-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(+)-Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction.3 (+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-Mdm2 interaction than ()-nutlin-3, demonstrating an IC50 value of 13.6 M. This inactive enantiomer can serve as a useful control for non-MDM2 related cellular activities.

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