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Axon 1880
CAS [675576-98-4]
MF C30H30Cl2N4O4MW 581.49
Nutlin-3a is an antagonist or inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53.
*Note: Nutlin-3a (Axon 1880) is the 150-fold more potent (-)-enantiomer of Nutlin-3 (Axon 1585), in comparision with the opposite (+)-enantiomer Nutlin-3b (Axon 1881). Presently, much attention has been given to Nutlin-3a and its absolute stereo-assignment is now known.
4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
[675576-98-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
Download the Axon Ligands™ catalogue 2021 Spring Edition
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