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ChemicalBook >> CAS DataBase List >> R428

R428

R428 price.
  • $50 - $5975
  • Product name: R428
  • CAS: 1037624-75-1
  • MF: C30H34N8
  • MW: 506.64
  • EINECS:
  • MDL Number:MFCD21608463
  • Synonyms:(S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine;BGB-324;BGB-324, CPDB1725;(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8;R428;R428 (BGB324);1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine;BGB324(R428,Bemcentinib)
30 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1131-M050
  • Product descriptionR428 ≥95%
  • Packaging50mg
  • Price$4212
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1131
  • Product descriptionR428
  • Packaging100mg
  • Price$5975
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171244
  • Product description(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+%
  • Packaging5mg
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171244
  • Product description(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+%
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171244
  • Product description(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+%
  • Packaging50mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171244
  • Product description(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+%
  • Packaging100mg
  • Price$295
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171244
  • Product description(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+%
  • Packaging250mg
  • Price$589
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA171244
  • Product description(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+%
  • Packaging1g
  • Price$1863
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0002537
  • Product descriptionR-428 95.00%
  • Packaging5MG
  • Price$501.66
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8329
  • Product descriptionR428
  • Packaging1mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8329
  • Product descriptionR428
  • Packaging5mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8329
  • Product descriptionR428
  • Packaging10mM(in 1mL DMSO)
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8329
  • Product descriptionR428
  • Packaging10mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8329
  • Product descriptionR428
  • Packaging50mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60075
  • Product descriptionBemcentinib(R428) ≥98%
  • Packaging5mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181109
  • Product descriptionR428 (BGB324) >98%
  • Packaging10mg
  • Price$510
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1131-M050 R428 ≥95% 50mg $4212 2021-12-16 Buy
AK Scientific SYN1131 R428 100mg $5975 2021-12-16 Buy
Ambeed A171244 (S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+% 5mg $81 2021-12-16 Buy
Ambeed A171244 (S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+% 10mg $135 2021-12-16 Buy
Ambeed A171244 (S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+% 50mg $227 2021-12-16 Buy
Ambeed A171244 (S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+% 100mg $295 2021-12-16 Buy
Ambeed A171244 (S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+% 250mg $589 2021-12-16 Buy
Ambeed A171244 (S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine 98+% 1g $1863 2021-12-16 Buy
American Custom Chemicals Corporation KIN0002537 R-428 95.00% 5MG $501.66 2021-12-16 Buy
ApexBio Technology A8329 R428 1mg $65 2021-12-16 Buy
ApexBio Technology A8329 R428 5mg $140 2021-12-16 Buy
ApexBio Technology A8329 R428 10mM(in 1mL DMSO) $156 2021-12-16 Buy
ApexBio Technology A8329 R428 10mg $250 2021-12-16 Buy
ApexBio Technology A8329 R428 50mg $470 2021-12-16 Buy
Arctom CFN60075 Bemcentinib(R428) ≥98% 5mg $218 2021-12-16 Buy
Biorbyt Ltd orb181109 R428 (BGB324) >98% 10mg $510 2021-12-16 Buy

Properties

Melting point :>211°C (dec.)
Boiling point :799.6±70.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Yellow powder.
pka :10.34±0.20(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

R428 (bemcentinib, BGB324), a selective small-molecule inhibitor of AXL, is currently being evaluated in phase II trials for the treatment of non-small-cell lung cancer (NSCLC) and acute myelocytic leukemia (AML). It has been found to induce apoptosis in cancer cells and to block tumor spread in models of metastatic breast cancer. The therapeutic potential of R428 has also been demonstrated in highly invasive esophageal adenocarcinoma cells and in ESCC cells.
R428 is a selective, small molecule inhibitor of Axl that blocks its catalytic and precancerous activities. R428 treatment reduced Axl-induced AKT phosphorylation, cancer cell invasion, angiogenesis, and the production of pro-inflammatory cytokines. It also reduced the expression of the cytokine granulocyte macrophage colony-stimulating factor and Snail in a dosage-dependent manner. Interestingly,using R428 to inhibit Axl-mediated cellular and molecular functions during cisplatin treatments achieved an enhanced suppression of liver metastases. Axl knockdowns in RAC cell lines reduced migration, invasion, and in vivo engraftment, accompanied by a downregulation in the activity of the Ral GTPase proteins (RalA and RalB). Similar effects were obtained using an A428 inhibitor. Blocking Axl functions also abrogated the phosphorylation of ERBB2 (Her-2/neu) at the Tyr877 residue, which reveals the cross-functional effects of R428 on different receptor signaling axes.
Cabozantinib (XL184) and R428 (BGB324) Inhibit the Growth of Esophageal Squamous Cell Carcinoma (ESCC)

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