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ChemicalBook >> CAS DataBase List >> LY 2874455

LY 2874455

LY 2874455 price.
  • $74 - $8042
  • Product name: LY 2874455
  • CAS: 1254473-64-7
  • MF: C21H19Cl2N5O2
  • MW: 444.31
  • EINECS:
  • MDL Number:MFCD22124884
  • Synonyms:LY 2874455;(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol;LY2874455/LY-2874455;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol LY2874455;(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethan-1-ol;(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl);(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL
30 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • 1000mg
  • ManufacturerAK Scientific
  • Product number2529AH
  • Product description(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
  • Packaging1g
  • Price$3047
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2529AH
  • Product description(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
  • Packaging5g
  • Price$8042
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3576
  • Product descriptionLY2874455
  • Packaging10mM(in 1mL DMSO)
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180852
  • Product descriptionLY-2874455 >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180852
  • Product descriptionLY-2874455 >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180852
  • Product descriptionLY-2874455 >98%
  • Packaging1000mg
  • Price$2839
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL137697
  • Product descriptionLY 2874455
  • Packaging10mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL137697
  • Product descriptionLY 2874455
  • Packaging50mg
  • Price$787.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20843
  • Product descriptionLY2874455 ≥98%
  • Packaging1mg
  • Price$74
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20843
  • Product descriptionLY2874455 ≥98%
  • Packaging5mg
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20843
  • Product descriptionLY2874455 ≥98%
  • Packaging10mg
  • Price$330
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20843
  • Product descriptionLY2874455 ≥98%
  • Packaging25mg
  • Price$437
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM150827
  • Product description(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol 98%
  • Packaging100mg
  • Price$808
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0907
  • Product descriptionLY2874455 98.06%
  • Packaging5mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0907
  • Product descriptionLY2874455 98.06%
  • Packaging10mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0907
  • Product descriptionLY2874455 98.06%
  • Packaging50mg
  • Price$816
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2529AH (R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol 1g $3047 2021-12-16 Buy
AK Scientific 2529AH (R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol 5g $8042 2021-12-16 Buy
ApexBio Technology A3576 LY2874455 10mM(in 1mL DMSO) $200 2021-12-16 Buy
Biorbyt Ltd orb180852 LY-2874455 >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb180852 LY-2874455 >98% 250mg $1504.5 2021-12-16 Buy
Biorbyt Ltd orb180852 LY-2874455 >98% 1000mg $2839 2021-12-16 Buy
Biosynth Carbosynth FL137697 LY 2874455 10mg $225 2021-12-16 Buy
Biosynth Carbosynth FL137697 LY 2874455 50mg $787.5 2021-12-16 Buy
Cayman Chemical 20843 LY2874455 ≥98% 1mg $74 2024-03-01 Buy
Cayman Chemical 20843 LY2874455 ≥98% 5mg $220 2024-03-01 Buy
Cayman Chemical 20843 LY2874455 ≥98% 10mg $330 2024-03-01 Buy
Cayman Chemical 20843 LY2874455 ≥98% 25mg $437 2024-03-01 Buy
Chemenu CM150827 (R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol 98% 100mg $808 2021-12-16 Buy
ChemScene CS-0907 LY2874455 98.06% 5mg $156 2021-12-16 Buy
ChemScene CS-0907 LY2874455 98.06% 10mg $252 2021-12-16 Buy
ChemScene CS-0907 LY2874455 98.06% 50mg $816 2021-12-16 Buy

Properties

Boiling point :672.6±55.0 °C(Predicted)
Density :1.44
storage temp. :Store at -20°C
solubility :≥44.4 mg/mL in DMSO; insoluble in H2O; ≥6.34 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :12.93±0.40(Predicted)
color :Pink to gray
CAS DataBase Reference :1254473-64-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.

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