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ChemicalBook >> CAS DataBase List >> LY-364947

LY-364947

LY-364947 price.
  • $45 - $18700
  • Product name: LY-364947
  • CAS: 396129-53-6
  • MF: C17H12N4
  • MW: 272.3
  • EINECS:
  • MDL Number:MFCD00800758
  • Synonyms:LY 364947 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline;LY-364947, 396129-53-6;Transforming Growth Factor-β Type I Receptor Kinase Inhibitor;LY-364947;LY-364947, >=98%;LY364947;HTS466284; LY-364947;TGF-β RI Kinase Inhibitor ;[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
38 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • SynQuest Laboratories
  • Tocris
  • TRC
  • Usbiological
Package
  • 616451-5MG
  • 5mg
  • 10mg
  • 25mg
  • 10
  • 1mg
  • 616451-5UNMG
  • 1
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 5G
  • 10G
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberX5937
  • Product description4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline
  • Packaging250mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000011
  • Product description4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00%
  • Packaging1G
  • Price$685.19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000011
  • Product description4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00%
  • Packaging5G
  • Price$1166.97
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000011
  • Product description4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00%
  • Packaging10G
  • Price$1740.95
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2287
  • Product descriptionLY364947
  • Packaging10mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2287
  • Product descriptionLY364947
  • Packaging10mM(in 1mL DMSO)
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2287
  • Product descriptionLY364947
  • Packaging25mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2287
  • Product descriptionLY364947
  • Packaging50mg
  • Price$259
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60332
  • Product descriptionLY364947
  • Packaging10mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180875
  • Product descriptionLY364947 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180875
  • Product descriptionLY364947 >98%
  • Packaging250mg
  • Price$1060.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180875
  • Product descriptionLY364947 >98%
  • Packaging1g
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13341
  • Product descriptionLY364947 ≥98%
  • Packaging5mg
  • Price$92
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13341
  • Product descriptionLY364947 ≥98%
  • Packaging10mg
  • Price$174
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13341
  • Product descriptionLY364947 ≥98%
  • Packaging25mg
  • Price$404
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13341
  • Product descriptionLY364947 ≥98%
  • Packaging50mg
  • Price$719
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5937 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline 250mg $110 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000011 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00% 1G $685.19 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000011 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00% 5G $1166.97 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000011 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00% 10G $1740.95 2021-12-16 Buy
ApexBio Technology B2287 LY364947 10mg $77 2021-12-16 Buy
ApexBio Technology B2287 LY364947 10mM(in 1mL DMSO) $81 2021-12-16 Buy
ApexBio Technology B2287 LY364947 25mg $189 2021-12-16 Buy
ApexBio Technology B2287 LY364947 50mg $259 2021-12-16 Buy
Arctom CFN60332 LY364947 10mg $138 2021-12-16 Buy
Biorbyt Ltd orb180875 LY364947 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb180875 LY364947 >98% 250mg $1060.8 2021-12-16 Buy
Biorbyt Ltd orb180875 LY364947 >98% 1g $1949.9 2021-12-16 Buy
Cayman Chemical 13341 LY364947 ≥98% 5mg $92 2024-03-01 Buy
Cayman Chemical 13341 LY364947 ≥98% 10mg $174 2024-03-01 Buy
Cayman Chemical 13341 LY364947 ≥98% 25mg $404 2024-03-01 Buy
Cayman Chemical 13341 LY364947 ≥98% 50mg $719 2024-03-01 Buy

Properties

Melting point :>230℃ (dec.)
Boiling point :490.8±45.0 °C(Predicted)
Density :1.283±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear
pka :8.94±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :IBCXZJCWDGCXQT-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Transforming growth factor-β (TGF-β) signals through a cell surface heteromeric complex involving type I (TGF-β RI) and type II (TGF-β RII) receptors. Downstream signal transduction is mediated by the TGF-β RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC50 value of 59 nM. LY364947 less effectively inhibits TGF-β RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and mixed-lineage kinase 7 (MLK7; IC50 = 1,400 nM). It inhibits TGF-β-induced cell growth (IC50 = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.

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