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ChemicalBook >> CAS DataBase List >> LY2811376

LY2811376

LY2811376 price.
  • $44 - $5880
  • Product name: LY2811376
  • CAS: 1194044-20-6
  • MF: C15H14F2N4S
  • MW: 320.36
  • EINECS:-0
  • MDL Number:MFCD18074525
  • Synonyms:LY2811376;(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine;LY 2811376,(4S)-4-[2,4-Difluoro-5-(5-pyriMidinyl)phenyl]-5,6-dihydro-4-Methyl-4H-1,3-thiazin-2-aMine;(S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine;(4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl LY2811376;LY2811376, >=98%;CS-1893
33 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1mg
  • 2.5mg
  • 5MG
  • 2x5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberY0285
  • Product descriptionLY2811376
  • Packaging1mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008041
  • Product descriptionLY2811376 95.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008041
  • Product descriptionLY2811376 95.00%
  • Packaging5MG
  • Price$500.28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4020
  • Product descriptionLY2811376
  • Packaging5mg
  • Price$197
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60435
  • Product descriptionLY2811376
  • Packaging10mg
  • Price$378
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2225
  • Product descriptionLY2811376 99%
  • Packaging2x5mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146284
  • Product descriptionLY2811376 >98%
  • Packaging100mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146284
  • Product descriptionLY2811376 >98%
  • Packaging250mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146284
  • Product descriptionLY2811376 >98%
  • Packaging1g
  • Price$3136.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL102501
  • Product descriptionLY 2811376
  • Packaging10mg
  • Price$225
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFL102501
  • Product descriptionLY 2811376
  • Packaging50mg
  • Price$787.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16712
  • Product descriptionLY2811376 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16712
  • Product descriptionLY2811376 ≥98%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16712
  • Product descriptionLY2811376 ≥98%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16712
  • Product descriptionLY2811376 ≥98%
  • Packaging50mg
  • Price$1062
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM167427
  • Product description(S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine 98%
  • Packaging100mg
  • Price$662
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0285 LY2811376 1mg $96 2021-12-16 Buy
American Custom Chemicals Corporation API0008041 LY2811376 95.00% 1MG $148.05 2021-12-16 Buy
American Custom Chemicals Corporation API0008041 LY2811376 95.00% 5MG $500.28 2021-12-16 Buy
ApexBio Technology A4020 LY2811376 5mg $197 2021-12-16 Buy
Arctom CFN60435 LY2811376 10mg $378 2021-12-16 Buy
Axon Medchem Axon2225 LY2811376 99% 2x5mg $220 2021-12-16 Buy
Biorbyt Ltd orb146284 LY2811376 >98% 100mg $986 2021-12-16 Buy
Biorbyt Ltd orb146284 LY2811376 >98% 250mg $1802 2021-12-16 Buy
Biorbyt Ltd orb146284 LY2811376 >98% 1g $3136.5 2021-12-16 Buy
Biosynth Carbosynth FL102501 LY 2811376 10mg $225 2021-12-16 Buy
Biosynth Carbosynth FL102501 LY 2811376 50mg $787.5 2021-12-16 Buy
Cayman Chemical 16712 LY2811376 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 16712 LY2811376 ≥98% 5mg $193 2024-03-01 Buy
Cayman Chemical 16712 LY2811376 ≥98% 10mg $341 2024-03-01 Buy
Cayman Chemical 16712 LY2811376 ≥98% 50mg $1062 2024-03-01 Buy
Chemenu CM167427 (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine 98% 100mg $662 2021-12-16 Buy

Properties

Boiling point :486.5±55.0 °C(Predicted)
Density :1.42
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :5.60±0.40(Predicted)
color :White to khaki

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Accumulation of the β-amyloid (Aβ) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer’s disease. Aβ is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. LY2811376 is a non-peptide inhibitor of BACE1 (IC50 = 239 nM for the synthetic peptide) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over the aspartyl proteases cathepsin D, pepsin, and renin. LY2811376 treatment in APP-overexpressing cells and transgenic animal models yields a dose-dependent decrease in Aβ. Furthermore, LY2811376 has been reported to reduce C99 and sAPPβ, the two primary APP cleavage products generated by BACE1.

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