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ChemicalBook >> CAS DataBase List >> Etoposide

Etoposide

Etoposide price.
  • $9 - $16790
  • Product name: Etoposide
  • CAS: 33419-42-0
  • MF: C29H32O13
  • MW: 588.56
  • EINECS:251-509-1
  • MDL Number:MFCD00869325
  • Synonyms:(-)-Etoposide, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside;EtoposideETOPOSIDE
    CAS:33419-42-0
    MES-012;BMY-40481, Etoposide 4'-Dihydrogenphosphate, VP-16-213;Etoposide , 98.0%(LC);Etoposide for system suitability;GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2;Etoposide, >=98%;(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
56 prices
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  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
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  • Chem-Impex
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  • Sigma-Aldrich
  • TCI Chemical
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  • Usbiological
Package
  • y0001365
  • e2600000
  • 10μg
  • 500μG
  • 5mg
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  • 10mM(in 1mL DMSO)
  • 150MG
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  • 1g
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  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3572-M100
  • Product descriptionEtoposide ≥98%(HPLC)
  • Packaging100mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberAPI-1234
  • Product descriptionEtoposide 98%
  • Packaging1g
  • Price$290
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ20643
  • Product descriptionEtoposide
  • Packaging10g
  • Price$427
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90059
  • Product descriptionEtoposide
  • Packaging25g
  • Price$680
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63651
  • Product descriptionEtoposide
  • Packaging25mg
  • Price$68.3
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63651
  • Product descriptionEtoposide
  • Packaging100mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA174646
  • Product descriptionEtoposide 98%
  • Packaging100mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174646
  • Product descriptionEtoposide 98%
  • Packaging250mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174646
  • Product descriptionEtoposide 98%
  • Packaging1g
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA174646
  • Product descriptionEtoposide 98%
  • Packaging5g
  • Price$171
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA1971
  • Product descriptionEtoposide
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1971
  • Product descriptionEtoposide
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023125
  • Product descriptionEtoposide 98%
  • Packaging100mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023125
  • Product descriptionEtoposide 98%
  • Packaging250mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023125
  • Product descriptionEtoposide 98%
  • Packaging1g
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN89061
  • Product descriptionEtoposide ≥98%
  • Packaging20mg
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3572-M100 Etoposide ≥98%(HPLC) 100mg $70 2021-12-16 Buy
AHH API-1234 Etoposide 98% 1g $290 2021-12-16 Buy
AK Scientific J20643 Etoposide 10g $427 2021-12-16 Buy
AK Scientific J90059 Etoposide 25g $680 2021-12-16 Buy
Alfa Aesar J63651 Etoposide 25mg $68.3 2024-03-01 Buy
Alfa Aesar J63651 Etoposide 100mg $169 2024-03-01 Buy
Ambeed A174646 Etoposide 98% 100mg $9 2021-12-16 Buy
Ambeed A174646 Etoposide 98% 250mg $12 2021-12-16 Buy
Ambeed A174646 Etoposide 98% 1g $37 2021-12-16 Buy
Ambeed A174646 Etoposide 98% 5g $171 2021-12-16 Buy
ApexBio Technology A1971 Etoposide 100mg $50 2021-12-16 Buy
ApexBio Technology A1971 Etoposide 10mM(in 1mL DMSO) $55 2021-12-16 Buy
Arctom AS023125 Etoposide 98% 100mg $9 2021-12-16 Buy
Arctom AS023125 Etoposide 98% 250mg $12 2021-12-16 Buy
Arctom AS023125 Etoposide 98% 1g $37 2021-12-16 Buy
Arctom CFN89061 Etoposide ≥98% 20mg $50 2021-12-16 Buy

Properties

Melting point :236-251 °C (lit.)
Boiling point :563.9°C (rough estimate)
alpha :D20 -110.5° (c = 0.6 in chloroform)
Density :1.2966 (rough estimate)
refractive index :-110.5 ° (C=0.6, CHCl3)
storage temp. :2-8°C
solubility :DMSO: 30 mg/mL
form :powder
pka :9.8(at 25℃)
color :white
Water Solubility :Insoluble in water.
Merck :14,3886
BCS Class :4
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
IARC :1 (Vol. 76, 100A) 2012, 1 (Vol. 76, 100A) 2012
EPA Substance Registry System :Etoposide (33419-42-0)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Etoposide is a plant alkaloid which acts as an inhibitor of topoisomerase II (IC50 = 60.3 μM). Notably, this compound can have much greater potencies when evaluated in cell-based cytotoxicity assays (e.g., IC50 = 5.14 nM for MCF-7 cells). Etoposide inhibits DNA synthesis by forming a ternary complex with DNA and topoisomerase II, inducing breaks in double stranded DNA. Accumulated breaks in DNA prevent entry into mitosis and lead to cell death. Recent bioassay data suggest that etoposide can also inhibit nuclear receptor coactivator 3 (IC50 = 2.48 μM), a steroid receptor coactivator with histone acetyltransferase activity. Interestingly, histone deacetylase inhibitors can sensitize multidrug-resistant cancer cells to etoposide.

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